Over 20 years ago, it was first proposed that autoinflammation underpins a handful of rare
monogenic disorders characterized by recurrent fever and systemic inflammation. The …

The pyrin inflammasome has evolved as an innate immune sensor to detect bacterial toxin-
induced Rho guanosine triphosphatase (Rho GTPase)-inactivation, a process that is similar …

Innate immune cells can develop long-term memory after stimulation by microbial products
during infections or vaccinations. Here, we report that metabolic signals can induce trained …

Background Different diagnostic and classification criteria are available for hereditary
recurrent fevers (HRF)—familial Mediterranean fever (FMF), tumour necrosis factor receptor …

Autoinflammatory diseases were first recognized nearly 20 years ago as distinct clinical and
immunological entities caused by dysregulation in the innate immune system. Since then …

Caspases are a family of endoproteases that provide critical links in cell regulatory networks
controlling inflammation and cell death. The activation of these enzymes is tightly controlled …

Inflammation is a complex set of interactions among soluble factors and cells that can arise
in any tissue in response to traumatic, infectious, post-ischaemic, toxic or autoimmune injury …

Familial cold autoinflammatory syndrome (FCAS, MIM 120100), commonly known as familial
cold urticaria (FCU), is an autosomal-dominant systemic inflammatory disease characterized …

The autoinflammatory diseases are characterized by seemingly unprovoked episodes of
inflammation, without high-titer autoantibodies or antigen-specific T cells. The concept was …

Mevalonate pathway is an important metabolic pathway which plays a key role in multiple
cellular processes by synthesizing sterol isoprenoids, such as cholesterol, and non-sterol …