Visible-to-NIR-light activated release: from small molecules to nanomaterials
Photoactivatable (alternatively, photoremovable, photoreleasable, or photocleavable)
protecting groups (PPGs), also known as caged or photocaged compounds, are used to …
protecting groups (PPGs), also known as caged or photocaged compounds, are used to …
Photocleavable Ortho-Nitrobenzyl-Protected DNA Architectures and Their Applications
This review article introduces mechanistic aspects and applications of photochemically
deprotected ortho-nitrobenzyl (ONB)-functionalized nucleic acids and their impact on …
deprotected ortho-nitrobenzyl (ONB)-functionalized nucleic acids and their impact on …
Optochemical control of biological processes in cells and animals
N Ankenbruck, T Courtney, Y Naro… - Angewandte Chemie …, 2018 - Wiley Online Library
Biological processes are naturally regulated with high spatial and temporal control, as is
perhaps most evident in metazoan embryogenesis. Chemical tools have been extensively …
perhaps most evident in metazoan embryogenesis. Chemical tools have been extensively …
Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia
For an epithelium to provide a protective barrier, it must maintain homeostatic cell numbers
by matching the number of dividing cells with the number of dying cells. Although …
by matching the number of dividing cells with the number of dying cells. Although …
[HTML][HTML] The zebrafish eye—a paradigm for investigating human ocular genetics
R Richardson, D Tracey-White, A Webster, M Moosajee - Eye, 2017 - nature.com
Although human epidemiological and genetic studies are essential to elucidate the
aetiology of normal and aberrant ocular development, animal models have provided us with …
aetiology of normal and aberrant ocular development, animal models have provided us with …
[HTML][HTML] Morpholinos: antisense and sensibility
M Blum, EM De Robertis, JB Wallingford, C Niehrs - Developmental cell, 2015 - cell.com
For over 15 years, antisense morpholino oligonucleotides (MOs) have allowed
developmental biologists to make key discoveries regarding developmental mechanisms in …
developmental biologists to make key discoveries regarding developmental mechanisms in …
Optochemical control of deoxyoligonucleotide function via a nucleobase-caging approach
Q Liu, A Deiters - Accounts of chemical research, 2014 - ACS Publications
Synthetic oligonucleotides have been extensively applied tocontrol a wide range of
biological processes such as gene expression, gene repair, DNA replication, and protein …
biological processes such as gene expression, gene repair, DNA replication, and protein …
Sequential gene silencing using wavelength‐selective caged morpholino oligonucleotides
S Yamazoe, Q Liu, LE McQuade… - Angewandte Chemie …, 2014 - Wiley Online Library
Spectrally differentiated caged morpholino oligonucleotides (cMOs) and wavelength‐
selective illumination have been used to sequentially inactivate organismal gene function …
selective illumination have been used to sequentially inactivate organismal gene function …
Small molecule control of morpholino antisense oligonucleotide function through staudinger reduction
Conditionally activated, caged morpholino antisense agents (cMOs) are tools that enable
the temporal and spatial investigation of gene expression, regulation, and function during …
the temporal and spatial investigation of gene expression, regulation, and function during …
Synthesis of phosphorodiamidate morpholino oligonucleotides using trityl and fmoc chemistry in an automated oligo synthesizer
Phosphorodiamidate morpholino oligonucleotides (PMOs) constitute 3 out of the 11 FDA-
approved oligonucleotide-based drugs in the last 6 years. PMOs can effectively silence …
approved oligonucleotide-based drugs in the last 6 years. PMOs can effectively silence …