The etiology of central precocious puberty (CPP) is multiple and heterogeneous, including
congenital and acquired causes that can be associated with structural or functional brain …

The pubertal development onset is controlled by a network of genes that regulate the
gonadotropin releasing hormone (GnRH) pulsatile release and the subsequent increase of …

Limited knowledge of cellular and molecular mechanisms underlying hematopoietic stem
cell and multipotent progenitor (HSC/MPP) expansion within their native niche has impeded …

Molecular mechanisms associated with human germ cell aplasia in infertile men remain
undefined. Here we perform single-cell transcriptome profiling to highlight differentially …

Gonadotrophin dependent sexual precocity, commonly referred to as central precocious
puberty (CPP), results from a premature reactivation of the hypothalamic-pituitary-gonadal …

Pubertal onset is known to result from reactivation of the hypothalamic-pituitary-gonadal
(HPG) axis, which is controlled by complex interactions of genetic and nongenetic factors …

Abstract Motivation Cell–cell interactions (CCIs) play critical roles in many biological
processes such as cellular differentiation, tissue homeostasis, and immune response. With …

PEG10 and PEG11/RTL1 are paternally expressed, imprinted genes that play essential
roles in the current eutherian developmental system and are therefore associated with …

Temple syndrome (TS) and Kagami-Ogata syndrome (KOS) are imprinting disorders caused
by absence or overexpression of genes within a single imprinted cluster on human …

Puberty is a developmental period characterized by a broad range of physiologic changes
necessary for the acquisition of adult sexual and reproductive maturity. These changes …