Every cell in nature carries a rich surface coat of glycans, its glycocalyx, which constitutes
the cell's interface with its environment. In eukaryotes, the glycocalyx is composed of …

Many cell adhesion molecules are localized at synaptic sites in neuronal axons and
dendrites. These molecules bridge pre-and postsynaptic specializations but do far more …

The mechanisms by which common risk variants of small effect interact to contribute to
complex genetic disorders are unclear. Here, we apply a genetic approach, using isogenic …

cAMP is a universal second messenger of many G-protein-coupled receptors and regulates
a wide variety of cellular events. cAMP exerts its effects via cAMP-dependent protein kinase …

Neuroligins enhance synapse formation in vitro, but surprisingly are not required for the
generation of synapses in vivo. We now show that in cultured neurons, neuroligin-1 …

The rapid growth of infant brains places an exceptionally high demand on the supply of
nutrients from the diet, particularly for preterm infants. Sialic acid (Sia) is an essential …

Polysialic acid (PSA) is a linear homopolymer of α2-8-N acetylneuraminic acid whose major
carrier in vertebrates is the neural cell adhesion molecule (NCAM). PSA serves as a potent …

Extracellular matrix molecules—including chondroitin sulfate proteoglycans, hyaluronan,
and tenascin‐R—are enriched in perineuronal nets (PNs) associated with subsets of …

The mammalian central nervous system (CNS) requires the proper formation of exquisitely
precise circuits to function correctly. These neuronal circuits are assembled during …

There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine
receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin …