The hygiene hypothesis in autoimmunity: the role of pathogens and commensals
JF Bach - Nature Reviews Immunology, 2018 - nature.com
The incidence of autoimmune diseases has been steadily rising. Concomitantly, the
incidence of most infectious diseases has declined. This observation gave rise to the …
incidence of most infectious diseases has declined. This observation gave rise to the …
T cell epitope predictions
Throughout the body, T cells monitor MHC-bound ligands expressed on the surface of
essentially all cell types. MHC ligands that trigger a T cell immune response are referred to …
essentially all cell types. MHC ligands that trigger a T cell immune response are referred to …
Improved prediction of MHC II antigen presentation through integration and motif deconvolution of mass spectrometry MHC eluted ligand data
B Reynisson, C Barra, S Kaabinejadian… - Journal of proteome …, 2020 - ACS Publications
Major histocompatibility complex II (MHC II) molecules play a vital role in the onset and
control of cellular immunity. In a highly selective process, MHC II presents peptides derived …
control of cellular immunity. In a highly selective process, MHC II presents peptides derived …
The effect of infections on susceptibility to autoimmune and allergic diseases
JF Bach - New England journal of medicine, 2002 - Mass Medical Soc
The hygiene hypothesis postulates that an environment with a high incidence of infectious
diseases protects against allergic and autoimmune diseases, whereas hygienic …
diseases protects against allergic and autoimmune diseases, whereas hygienic …
The staphylococcal enterotoxins and their relatives
P Marrack, J Kappler - Science, 1990 - science.org
Staphylococcal enterotoxins and a group of related proteins made by Streptococci cause
food poisoning and shock in man and animals. These proteins share an ability to bind to …
food poisoning and shock in man and animals. These proteins share an ability to bind to …
MHC ligands and peptide motifs: first listing
HG Rammensee, T Friede, S Stevanović - Immunogenetics, 1995 - Springer
The purpose of this article is to provide a compendium of major histocompatibility complex
(MHC) peptide motifs and MHC ligands known to date, together with a discussion of the …
(MHC) peptide motifs and MHC ligands known to date, together with a discussion of the …
NetMHCpan, a Method for Quantitative Predictions of Peptide Binding to Any HLA-A and -B Locus Protein of Known Sequence
Background Binding of peptides to Major Histocompatibility Complex (MHC) molecules is
the single most selective step in the recognition of pathogens by the cellular immune system …
the single most selective step in the recognition of pathogens by the cellular immune system …
Several common HLA-DR types share largely overlapping peptide binding repertoires
S Southwood, J Sidney, A Kondo… - The Journal of …, 1998 - journals.aai.org
The peptide binding specificities of HLA-DRB1* 0401, DRB1* 0101, and DRB1* 0701 have
been analyzed by the use of large collections of synthetic peptides corresponding to …
been analyzed by the use of large collections of synthetic peptides corresponding to …
Introduction of soluble protein into the class I pathway of antigen processing and presentation
MW Moore, FR Carbone, MJ Bevan - Cell, 1988 - cell.com
In order to investigate how peptides associate with class I major histocompatibility complex
(MHC) glycoproteins intracellularly, we generated cytotoxic T lymphoyctes (CTL) specific for …
(MHC) glycoproteins intracellularly, we generated cytotoxic T lymphoyctes (CTL) specific for …
Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 Å resolution
MA Saper, PJ Bjorkman, DC Wiley - Journal of molecular biology, 1991 - Elsevier
The three-dimensional structure of the human histocompatibility antigen HLA-A2 was
determined at 3.5 Å resolution by a combination of isomorphous replacement and iterative …
determined at 3.5 Å resolution by a combination of isomorphous replacement and iterative …