Now you see me, now you don't: the interaction of Salmonella with innate immune receptors

AM Keestra-Gounder, RM Tsolis… - Nature Reviews …, 2015 - nature.com
Salmonella enterica serovars are associated with an estimated 1 million deaths annually
and are also useful model organisms for investigating the mechanisms of host–bacterium …

Impact of Salmonella enterica Type III Secretion System Effectors on the Eukaryotic Host Cell

F Ramos-Morales - International Scholarly Research Notices, 2012 - Wiley Online Library
Type III secretion systems are molecular machines used by many Gram‐negative bacterial
pathogens to inject proteins, known as effectors, directly into eukaryotic host cells. These …

Manipulation of small Rho GTPases is a pathogen-induced process detected by NOD1

AM Keestra, MG Winter, JJ Auburger, SP Fräßle… - Nature, 2013 - nature.com
Our innate immune system distinguishes microbes from self by detecting conserved
pathogen-associated molecular patterns. However, these are produced by all microbes …

[HTML][HTML] The human milk oligosaccharide 2′-fucosyllactose quenches campylobacter jejuni–induced inflammation in human epithelial cells HEp-2 and HT-29 and in …

ZT Yu, NN Nanthakumar, DS Newburg - The Journal of nutrition, 2016 - Elsevier
Background: Campylobacter jejuni causes diarrhea worldwide; young children are most
susceptible. Binding of virulent C. jejuni to the intestinal mucosa is inhibited ex vivo by α 1, 2 …

VopV, an F-actin-binding type III secretion effector, is required for Vibrio parahaemolyticus-induced enterotoxicity

H Hiyoshi, T Kodama, K Saito, K Gotoh, S Matsuda… - Cell host & …, 2011 - cell.com
Vibrio parahaemolyticus, a Gram-negative halophilic bacterium that causes acute
gastroenteritis in humans, is characterized by two type III secretion systems (T3SS), namely …

A Salmonella Virulence Factor Activates the NOD1/NOD2 Signaling Pathway

A Marijke Keestra, MG Winter, D Klein-Douwel… - MBio, 2011 - Am Soc Microbiol
The invasion-associated type III secretion system (T3SS-1) of Salmonella enterica serotype
Typhimurium (S. Typhimurium) activates the transcription factor NF-κB in tissue culture cells …

Ehrlichia Notch signaling induction promotes XIAP stability and inhibits apoptosis

LNL Patterson, CD Byerly, R Solomon… - Infection and …, 2023 - Am Soc Microbiol
Ehrlichia chaffeensis has evolved multiple strategies to evade innate defenses of the
mononuclear phagocyte. Recently, we reported the E. chaffeensis tandem repeat protein …

Salmonella enterica Serovar Typhi Conceals the Invasion-Associated Type Three Secretion System from the Innate Immune System by Gene Regulation

SE Winter, MG Winter, V Poon, AM Keestra… - PLoS …, 2014 - journals.plos.org
Delivery of microbial products into the mammalian cell cytosol by bacterial secretion systems
is a strong stimulus for triggering pro-inflammatory host responses. Here we show that …

A role for the Salmonella Type III Secretion System 1 in bacterial adaptation to the cytosol of epithelial cells

A Chong, T Starr, CE Finn… - Molecular …, 2019 - Wiley Online Library
Salmonella enterica serovar Typhimurium is a facultative intracellular pathogen that invades
the intestinal epithelium. Following invasion of epithelial cells, Salmonella survives and …

The role of neutrophils in the event of intestinal inflammation

KL Mumy, BA McCormick - Current opinion in pharmacology, 2009 - Elsevier
The transmigration of polymorphonuclear leukocytes (PMNs; neutrophils) into the intestinal
lumen is a classical phenomenon associated with a wide variety of disease states, including …