Metastasis is a multistep process in which tumor extracellular matrix (ECM) and cancer cell
cytoskeleton interactions are pivotal. ECM is connected, through integrins, to the cell's …

Combinatorial conjugation of organ-on-a-chip platforms with additive manufacturing
technologies is rapidly emerging as a disruptive approach for upgrading cancer-on-a-chip …

Tumors can undergo long periods of dormancy, with cancer cells entering a largely
quiescent, nonproliferative state before reactivation and outgrowth. To understand the role of …

In this work, we show how the mechanical properties of the cellular microenvironment
modulate the growth of tumour spheroids. Based on the composition of the extracellular …

Cancer cells have the ability to migrate from the primary (original) site to other places in the
body. The extracellular matrix affects cancer cell migratory capacity and has been correlated …

Bioengineers have designed numerous instructive brain extracellular matrix (ECM)
environments with tailored and tunable protein compositions and biomechanical properties …

Mechanotransduction is a physiological process in which external mechanical stimulations
are perceived, interpreted, and translated by cells into biochemical signals. Mechanical …

Colorectal cancer and other cancers often metastasize to the liver in later stages of the
disease, contributing significantly to patient death. While the biomechanical properties of the …

Cancer metastasis, the spread of cancer cells to distant organs, is responsible for 90% of
cancer‐related deaths. Cancer cells need to enter and exit circulation in order to form …

Most patients who succumb to cancer have metastases to bone that contribute to their death.
Cancer cells that metastasize to bone are regularly subjected to mechanical stimuli that may …