The metabolic functions of androgen receptor (AR) in normal prostate are circumvented in
prostate cancer (PCa) to drive tumor growth, and the AR also can acquire new growth …

Androgens, acting through the androgen receptor (AR), are responsible for the development
of the male phenotype during embryogenesis, the achievement of sexual maturation at …

Hes and Hey genes are the mammalian counterparts of the Hairy and Enhancer-of-split type
of genes in Drosophila and they represent the primary targets of the Delta–Notch signaling …

Histologic transformation to small cell neuroendocrine prostate cancer occurs in a subset of
patients with advanced prostate cancer as a mechanism of treatment resistance …

Prostate cancer remains a leading cause of cancer death, as there are no durable means to
treat advanced disease. Treatment of non-organ-confined prostate cancer hinges on its …

The transcriptional programs regulated through the activity of the androgen receptor (AR)
modulate normal prostate development and the maintenance of prostatic functions at …

The androgen receptor signaling axis plays an essential role in the development, function
and homeostasis of male urogenital structures including the prostate gland although the …

Steroid hormones are important endocrine signalling molecules controlling reproduction,
development, metabolism, salt balance and specialized cellular responses, such as …

Accumulating data indicate that there is significant genetic heterogeneity underlying the
etiology in individuals diagnosed with autism spectrum disorder (ASD). Some rare and …

The transcriptome of every cell is orchestrated by the complex network of interaction
between transcription factors (TFs) and their binding sites on DNA. Disruption of this network …