[HTML][HTML] NLRP3 Inflammasome-Mediated Osteoarthritis: The Role of Epigenetics
Y Liu, Y Wang, P Yan, N Cui, K Xu, D Liu, Y Tian… - …, 2025 - pmc.ncbi.nlm.nih.gov
The prevalence of osteoarthritis (OA) notably surges with age and weight gain. The most
common clinical therapeutic drugs are painkillers, yet they cannot impede the deteriorating …
common clinical therapeutic drugs are painkillers, yet they cannot impede the deteriorating …
[HTML][HTML] The pivotal role of histidine 976 in human histone deacetylase 4 for enzyme function and ligand recognition
M Schweipert, T Nehls, E Wurster, J Böltner, K Anton… - Bioorganic …, 2024 - Elsevier
Abstract Human histone deacetylase 4 (HDAC4) belongs to class IIa of the zinc-dependent
histone deacetylases. HDAC4 is an established target for various indication areas, in …
histone deacetylases. HDAC4 is an established target for various indication areas, in …
Super-enhancers reorganization controls re-sensitization of oxaliplatin-resistant FBXW7-mutated colorectal cancer
E Di Giorgio, V Tolotto, N Gualandi, M Colitti, R Picco… - 2024 - researchsquare.com
Epigenetic plasticity and large-scale chromatin remodeling characterize tumor evolution and
the emergence of subclones resistant to conventional therapies. Catalytically inactive class …
the emergence of subclones resistant to conventional therapies. Catalytically inactive class …