Since 2003, several loss-of-function mutations in the HCN4 gene, which encodes the HCN4
protein, have been associated with sinus node dysfunction. In human sinoatrial node (SAN) …

Cardiac myocytes are characterized by distinct structural and functional entities involved in
the generation and transmission of the action potential and the excitation-contraction …

Background and objectives. The creation of cardiomyocytes derived from human induced
pluripotent stem cells (hiPS-CMs) has spawned broad excitement borne out of the prospects …

Inflammatory pain hypersensitivity results partly from hyperexcitability of nociceptive
(damage-sensing) dorsal root ganglion (DRG) neurons innervating inflamed tissue …

Hyperpolarization-activated, cyclic nucleotide-sensitive (HCN) channels are key regulators
of subthreshold membrane potentials in excitable cells. The four mammalian HCN channel …

Fibrosis following myocardial infarction is associated with increases in arrhythmias and
sudden cardiac death. Initial steps in the development of fibrosis are not clear; however, it is …

Abstract Properties of the funny current (I f) have been studied in several animal and cellular
models, but so far little is known concerning its properties in human pacemaker cells. This …

The hyperpolarization-activated 'funny'current, I f, plays an important modulating role in the
pacemaker activity of the human sinoatrial node (SAN). I f is carried by hyperpolarization …

Pacemaker (HCN) channels have a key role in the generation and modulation of
spontaneous activity of sinoatrial node myocytes. Previous work has shown that …

Ion channels in excitable cells function in macromolecular complexes in which auxiliary
proteins modulate the biophysical properties of the pore-forming subunits. Hyperpolarization …