Biotechnical production processes often operate with plasmid‐based expression systems in
well‐established prokaryotic and eukaryotic hosts such as Escherichia coli or …

Francisella tularensis is a facultative intracellular gram-negative pathogen and the
etiological agent of the zoonotic disease tularemia. Recent advances in the field of …

In recent years, studies on the intracellular pathogen Francisella tularensis have greatly
intensified, generating a wealth of new information on the interaction of this organism with …

To generate an inexpensive readily manufactured COVID-19 vaccine, we employed the LVS
Δ capB vector platform, previously used to generate potent candidate vaccines against …

Francisella tularensis can cause fatal respiratory tularemia in humans and animals and is
increasingly being isolated in the United States and several European countries. The …

For several intracellular infections, pulmonary vaccination provides measurably better
protection against pulmonary challenge. The unique factors that contribute to pulmonary …

The environmental conditions generated by war and characterized by poverty,
undernutrition, stress, difficult access to safe water and food as well as lack of environmental …

Francisella tularensis, the highly virulent etiologic agent of tularemia, is a low-dose
intracellular pathogen that is able to escape from the phagosome and replicate in the …

Numerous studies have demonstrated that targeting Ag to Fc receptors (FcR) on APCs can
enhance humoral and cellular immunity. However, studies are lacking that examine both the …

Background Francisella tularensis is a highly virulent human pathogen. The most virulent
strains belong to subspecies tularensis and these strains cause a sometimes fatal disease …