Purpose The role of perineural invasion (PNI) in the management of patients with oral
squamous cell carcinoma (OSSC) is still controversial, and there is no consensus regarding …

Background In recent years have been observed an increased incidence of OSCC in young
individuals. Based on this, the aim this study was to describe the clinical characteristics of all …

Simple Summary The complex interplay between the different cellular components in the
tumor microenvironment (TME) dynamically modulates the antitumor immune response. This …

Head and neck squamous cell carcinoma (HNSCC) is known to cause substantial
immunosuppression. The present study was designed to characterize blood leukocyte …

Introduction In patients with squamous cell carcinoma (SCC) of the lip, occurrence of lymph
node metastasis (LNM) is more frequent than in other cutaneous head and neck SCCs. The …

PURPOSE: In this retrospective study, the aim was to compare individual histopathologic
parameters of malignancy between nonmetastatic and metastatic squamous cell carcinoma …

Background Natural killer (NK) cells are important immune effector cells against tumors
especially in the absence or reducing MHC class I antigen. Downregulation of CD 16 …

Background: The use of p16 and p53 as biomarkers of malignant transformation of oral
epithelial dysplasia (OED) and biological behavior of oral squamous cell carcinoma (OSCC) …

Purpose The aim of this study was to evaluate the population of CD8+ and natural killer (NK)
cells in samples of oral (OSCC) and oropharyngeal (OPSCC) squamous cell carcinoma …

Objectives Programmed death ligand-1 (PD-L1) and human leukocyte antigen-G (HLA-G)
are considered immune checkpoint molecules that inhibit T-cell effectiveness, contributing to …