Tumour mutational burden as a biomarker for immunotherapy: current data and emerging concepts

JD Fumet, C Truntzer, M Yarchoan… - European Journal of …, 2020 - Elsevier
Abstract Treatment with immune checkpoint inhibitors targeting programmed cell death
protein 1 (PD-1) or its ligand (PD-L1) can generate durable responses in various cancer …

Basis of PD1/PD-L1 therapies

B Seliger - Journal of clinical medicine, 2019 - mdpi.com
It is obvious that tumor cells have developed a number of strategies to escape immune
surveillance including an altered expression of various immune checkpoints, such as the …

Gut metabolomics profiling of non-small cell lung cancer (NSCLC) patients under immunotherapy treatment

A Botticelli, P Vernocchi, F Marini… - Journal of translational …, 2020 - Springer
Background Despite the efficacy of immune checkpoint inhibitors (ICIs) only the 20–30% of
treated patients present long term benefits. The metabolic changes occurring in the gut …

Utility of CT radiomics for prediction of PD‐L1 expression in advanced lung adenocarcinomas

J Yoon, YJ Suh, K Han, H Cho, HJ Lee, J Hur… - Thoracic …, 2020 - Wiley Online Library
Background We aimed to assess if quantitative radiomic features can predict programmed
death ligand 1 (PD‐L1) expression in advanced stage lung adenocarcinoma. Methods This …

Expert opinion on NSCLC small specimen biomarker testing—Part 2: Analysis, reporting, and quality assessment

F Penault-Llorca, KM Kerr, P Garrido, E Thunnissen… - Virchows Archiv, 2022 - Springer
The diagnostic work-up for non-small cell lung cancer (NSCLC) requires biomarker testing
to guide therapy choices. This article is the second of a two-part series. In Part 1, we …

[HTML][HTML] PD-1 blockade in recurrent or metastatic cervical cancer: Data from cemiplimab phase I expansion cohorts and characterization of PD-L1 expression in …

D Rischin, M Gil-Martin, A González-Martin, I Braña… - Gynecologic …, 2020 - Elsevier
Objectives To characterize the safety, tolerability, and anti-tumor activity of cemiplimab as
monotherapy or in combination with hypofractionated radiation therapy (hfRT) in patients …

Precision medicine for NSCLC in the era of immunotherapy: new biomarkers to select the most suitable treatment or the most suitable patient

G Rossi, A Russo, M Tagliamento, A Tuzi, O Nigro… - Cancers, 2020 - mdpi.com
In recent years, the evolution of treatments has made it possible to significantly improve the
outcomes of patients with non-small cell lung cancer (NSCLC). In particular, while molecular …

Detailed characterization of immune cell infiltrate and expression of immune checkpoint molecules PD-L1/CTLA-4 and MMR proteins in testicular germ cell tumors …

J Lobo, Â Rodrigues, R Guimarães, M Cantante… - Cancers, 2019 - mdpi.com
Background: The immune infiltrate plays an important part in testicular germ cell tumors, but
it remains scarcely studied. We aimed at thoroughly characterizing the immune infiltrate and …

Deep learning of histopathological features for the prediction of tumour molecular genetics

P Murchan, C Ó'Brien, S O'Connell, CS McNevin… - Diagnostics, 2021 - mdpi.com
Advanced diagnostics are enabling cancer treatments to become increasingly tailored to the
individual through developments in immunotherapies and targeted therapies. However, long …

PD-L1 Expression in Pituitary Neuroendocrine Tumors/Pituitary Adenomas

G Cossu, S La Rosa, JP Brouland, N Pitteloud, E Harel… - Cancers, 2023 - mdpi.com
Simple Summary The biological behavior of Pituitary Neuroendocrine Tumors (PitNET)
remains unclear. Many efforts have been performed in order to clarify this point. The …