Adenoviruses have been characterized extensively since their initial description in the early
1950s (Hillemann & Werner, 1954; Rowe et al., 1953) and there is now a panoply of …

Purpose: Adoptive T-cell immunotherapy with tumor infiltrating lymphocytes or genetically-
modified T cells has yielded dramatic results in some cancers. However, T cells need to …

Purpose To evaluate the feasibility and safety of intratumoral injection of an adenoviral
vector encoding human interleukin-12 genes (Ad. IL-12) and secondarily, its biologic effect …

The selective activation of prodrug (s) in tumor tissues by exogenous enzyme (s) for cancer
therapy can be accomplished by several ways, including gene-directed enzyme prodrug …

Malignant pleural mesothelioma (MPM) is a deadly disease that occurs in 2,000 to 3,000
people each year in the United States. Although MPM is an extremely difficult disease to …

This review is a survey of various approaches to targeting cytotoxic anticancer drugs to
tumors primarily through biomolecules expressed by cancer cells or associated vasculature …

BACKGROUND: Preclinical studies in animal models have demonstrated tumor regression
following intratumoral administration of an adenovirus vector containing wild-type p53 …

We are developing quantitative assays to repeatedly and noninvasively image expression of
reporter genes in living animals, using positron emission tomography (PET). We synthesized …

9-[4-[18F] fluoro-3-(hydroxymethyl) butyl] guanine ([18F] FHBG) has been used as a reporter
probe to image expression of herpes simplex virus type-1 thymidine kinase (HSV1-tk) …

For patients with local recurrence of prostate cancer after definitive irradiation therapy there
is no treatment widely considered safe and effective. After extensive preclinical testing of …