Microglia in the neuroinflammatory pathogenesis of Alzheimer's disease and related therapeutic targets

Y Cai, J Liu, B Wang, M Sun, H Yang - Frontiers in immunology, 2022 - frontiersin.org
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease worldwide,
characterized by progressive neuron degeneration or loss due to excessive accumulation of …

[HTML][HTML] TREM2: Potential therapeutic targeting of microglia for Alzheimer's disease

Y Li, H Xu, H Wang, K Yang, J Luan, S Wang - Biomedicine & …, 2023 - Elsevier
Alzheimer's disease (AD) is the most common neurodegenerative disease, resulting in the
loss of cognitive ability and memory. However, there is no specific treatment to …

Gram-negative bacteria and their lipopolysaccharides in Alzheimer's disease: pathologic roles and therapeutic implications

H Kim, S Kim, SJ Shin, YH Park, Y Nam, C Kim… - Translational …, 2021 - Springer
Alzheimer's disease (AD) is the most serious age-related neurodegenerative disease and
causes destructive and irreversible cognitive decline. Failures in the development of …

The P2X7 Receptor in Microglial Cells Modulates the Endolysosomal Axis, Autophagy, and Phagocytosis

KE Campagno, CH Mitchell - Frontiers in cellular neuroscience, 2021 - frontiersin.org
Microglial cells regulate neural homeostasis by coordinating both immune responses and
clearance of debris, and the P2X7 receptor for extracellular ATP plays a central role in both …

Low-dose ionizing radiation as a hormetin: experimental observations and therapeutic perspective for age-related disorders

A Vaiserman, JM Cuttler, Y Socol - Biogerontology, 2021 - Springer
Hormesis is any kind of biphasic dose-response when low doses of some agents are
beneficial while higher doses are detrimental. Radiation hormesis is the most thoroughly …

Control of neuroinflammation through radiation-induced microglial changes

A Boyd, S Byrne, RJ Middleton, RB Banati, GJ Liu - Cells, 2021 - mdpi.com
Microglia, the innate immune cells of the central nervous system, play a pivotal role in the
modulation of neuroinflammation. Neuroinflammation has been implicated in many diseases …

Glial polarization in neurological diseases: molecular mechanisms and therapeutic opportunities

Y Liu, L Wu, W Peng, X Mao - Ageing Research Reviews, 2024 - Elsevier
Glial cell polarization plays a pivotal role in various neurological disorders. In response to
distinct stimuli, glial cells undergo polarization to either mitigate neurotoxicity or facilitate …

Biomimetic Nanovesicles as a Dual Gene Delivery System for the Synergistic Gene Therapy of Alzheimer's Disease

S Jiang, G Cai, Z Yang, H Shi, H Zeng, Q Ye, Z Hu… - ACS …, 2024 - ACS Publications
The association between dysfunctional microglia and amyloid-β (Aβ) is a fundamental
pathological event and increases the speed of Alzheimer's disease (AD). Additionally, the …

Low doses of ionizing radiation as a treatment for Alzheimer's disease: a pilot study

JM Cuttler, E Abdellah, Y Goldberg… - Journal of …, 2021 - content.iospress.com
Background: In 2015, a patient in hospice with Alzheimer's disease (AD) was treated with
ionizing radiation to her brain using repeated CT scans. Improvement in cognition, speech …

Development of a 213bi-labeled pyridyl benzofuran for targeted α-therapy of amyloid-β aggregates

AA Bender, EK Kirkeby, DJ Cross… - Journal of Nuclear …, 2024 - jnm.snmjournals.org
Alzheimer disease is a neurodegenerative disorder with limited treatment options. It is
characterized by the presence of several biomarkers, including amyloid-β aggregates, which …