Antimalarial drug resistance, in particular resistance to Plasmodium falciparum, challenges
the treatment and control of malaria. In this Review, we summarise evolving patterns of …

Worldwide spread of Plasmodium falciparum drug resistance to conventional antimalarials,
chloroquine and sulfadoxine/pyrimethamine, has been imposing a serious public health …

Chloroquine (CQ) resistance (CQR) in Plasmodium falciparum originated from at least six
foci in South America, Asia, and Oceania. Malaria parasites from these locations exhibit …

Malaria represents one of the most serious threats to human health worldwide, and
preventing and curing this parasitic disease still depends predominantly on the …

Malaria is a protozoan disease transmitted by the bite of the Anopheles mosquito. Among
five species that can infect humans, Plasmodium falciparum is responsible for the most …

Abstract Background Increased resistance by Plasmodium falciparum parasites led to the
withdrawal of the antimalarial drugs chloroquine and sulphadoxine-pyrimethamine in …

Malaria has always been an important public health problem in Brazil. The early history of
Brazilian malaria and its control was powered by colonisation by Europeans and the forced …

The emergence and spread of antimalarial resistance has been a major liability for malaria
control. The spread of chloroquine-resistant Plasmodium falciparum strains had catastrophic …

Malaria continues to exert a tremendous health burden on human populations, reflecting
astonishingly successful adaptations of the causative Plasmodium parasites. We discuss …

Background Plasmodium falciparum is an apicomplexan parasite responsible for lethal
cases of malaria. According to WHO recommendations, P falciparum cases are treated with …