Intercellular signaling molecules, known as morphogens, act at a long range in developing
tissues to provide spatial information and control properties such as cell fate and tissue …

Mechanical forces shape cells and tissues during development and adult homeostasis. In
addition, they also signal to cells via mechanotransduction pathways to control cell …

INTRODUCTION Stem cell–derived organoids are in vitro tissue and organ mimetics that
have enormous potential as models for human organ development and disease, as …

Biomolecular and physical cues of the extracellular matrix environment regulate collective
cell dynamics and tissue patterning. Nonetheless, how the viscoelastic properties of the …

Development of the human intestine is not well understood. Here, we link single-cell RNA
sequencing and spatial transcriptomics to characterize intestinal morphogenesis through …

How the shape of embryos and organs emerges during development is a fundamental
question that has fascinated scientists for centuries. Tissue dynamics arise from a small set …

Surface curvature both emerges from, and influences the behavior of, living objects at length
scales ranging from cell membranes to single cells to tissues and organs. The relevance of …

Cancers are not composed merely of cancer cells alone; instead, they are complex
'ecosystems' comprising many different cell types and noncellular factors. The tumour stroma …

Among all cells, fibroblasts could be considered the cockroaches of the human body. They
survive severe stress that is usually lethal to all other cells, and they are the only normal cell …

Tissues that undergo rapid cellular turnover, such as the mammalian haematopoietic system
or the intestinal epithelium, are dependent on stem and progenitor cells that proliferate to …