Infectious diarrhea: Cellular and molecular mechanisms

K Hodges, R Gill - Gut microbes, 2010 - Taylor & Francis
Diarrhea caused by enteric infections is a major factor in morbidity and mortality worldwide.
An estimated 2-4 billion episodes of infectious diarrhea occur each year and are especially …

[HTML][HTML] The Role of Ion Transporters in the Pathophysiology of InfectiousáDiarrhea

S Das, R Jayaratne, KE Barrett - Cellular and molecular gastroenterology …, 2018 - Elsevier
Every year, enteric infections and associated diarrhea kill millions of people. The situation is
compounded by increases in the number of enteric pathogens that are acquiring resistance …

Immunization with a chimera consisting of the B subunit of Shiga toxin type 2 and brucella lumazine synthase confers total protection against Shiga toxins in mice

MP Mejias, G Ghersi, PO Craig, CA Panek… - The Journal of …, 2013 - journals.aai.org
The striking feature of enterohemorrhagic Escherichia coli (EHEC) infections is the
production of Shiga toxins (Stx) implicated in the development of the life-threatening …

[HTML][HTML] Intestinal secretory mechanisms in Okadaic acid induced diarrhoea

C Costas, MC Louzao, S Raposo-García, C Vale… - Food and Chemical …, 2022 - Elsevier
Okadaic acid (OA) is an important marine lipophilic phycotoxin responsible for diarrhetic
shellfish poisoning (DSP). This toxin inhibits protein phosphatases (PPs) like PP2A and …

[HTML][HTML] Vaccination of pregnant cows with EspA, EspB, γ-intimin, and Shiga toxin 2 proteins from Escherichia coli O157: H7 induces high levels of specific colostral …

BC Rabinovitz, E Gerhardt, CT Farinati, A Abdala… - Journal of dairy …, 2012 - Elsevier
Enterohemorrhagic Escherichia coli (EHEC) O157: H7 is a major cause of intestinal disease
and hemolytic uremic syndrome, a serious systemic complication that particularly affects …

[HTML][HTML] Cytotoxic effect of Shiga toxin-2 holotoxin and its B subunit on human renal tubular epithelial cells

VP Creydt, C Silberstein, E Zotta, C Ibarra - Microbes and infection, 2006 - Elsevier
Shiga toxin-producing Escherichia coli produces watery diarrhea, hemorrhagic colitis and
hemolytic–uremic syndrome (HUS). In Argentina, HUS is the most common cause of acute …

A glucosylceramide synthase inhibitor protects rats against the cytotoxic effects of shiga toxin 2

C Silberstein, MS Lucero, E Zotta, DP Copeland… - Pediatric …, 2011 - nature.com
Postdiarrhea hemolytic uremic syndrome is the most common cause of acute renal failure in
children in Argentina. Renal damage has been strongly associated with Shiga toxin (Stx) …

An orally applicable Shiga toxin neutralizer functions in the intestine to inhibit the intracellular transport of the toxin

M Watanabe-Takahashi, T Sato, T Dohi… - Infection and …, 2010 - Am Soc Microbiol
ABSTRACT Shiga toxin 2 (Stx2) is a major virulence factor in infections with Stx-producing
Escherichia coli (STEC), which causes gastrointestinal diseases and sometimes fatal …

Efficacy of a recombinant Intimin, EspB and Shiga toxin 2B vaccine in calves experimentally challenged with Escherichia coli O157: H7

L Martorelli, N Garimano, GA Fiorentino, DA Vilte… - Vaccine, 2018 - Elsevier
Escherichia coli O157: H7 is a zoonotic pathogen of global importance and the serotype of
Shiga toxin-producing E. coli (STEC) most frequently associated with Hemolytic Uremic …

A DNA Vaccine Encoding the Enterohemorragic Escherichia coli Shiga-Like Toxin 2 A2 and B Subunits Confers Protective Immunity to Shiga Toxin Challenge in the …

LV Bentancor, M Bilen, RJF Brando… - Clinical and Vaccine …, 2009 - Am Soc Microbiol
Production of verocytotoxin or Shiga-like toxin (Stx), particularly Stx2, is the basis of
hemolytic uremic syndrome, a frequently lethal outcome for subjects infected with Stx2 …