Targeted therapy in advanced non-small cell lung cancer: current advances and future trends

U Majeed, R Manochakian, Y Zhao, Y Lou - Journal of hematology & …, 2021 - Springer
Lung cancer remains the leading cause of cancer-related mortality in both men and women
in the US and worldwide. Non-small cell lung cancer is the most common variety accounting …

Global pattern and trends of colorectal cancer survival: a systematic review of population-based registration data

Y Jiang, H Yuan, Z Li, X Ji, Q Shen… - Cancer Biology & …, 2021 - pmc.ncbi.nlm.nih.gov
This review will describe the global patterns and trends of colorectal cancer survival, using
data from the population-based studies or cancer registration. We performed a systematic …

[HTML][HTML] Five year survival update from KEYNOTE-010: pembrolizumab versus docetaxel for previously treated, programmed death-ligand 1–positive advanced …

RS Herbst, EB Garon, DW Kim, BC Cho… - Journal of Thoracic …, 2021 - Elsevier
Introduction In the KEYNOTE-010 study, pembrolizumab improved overall survival (OS)
versus docetaxel in patients with previously treated, advanced NSCLC with programmed …

Umbralisib, a dual PI3Kδ/CK1ε inhibitor in patients with relapsed or refractory indolent lymphoma

NH Fowler, F Samaniego, W Jurczak… - Journal of Clinical …, 2021 - ascopubs.org
PURPOSE Phosphatidylinositol-3-kinase (PI3K) inhibitors have shown activity in relapsed or
refractory (R/R) indolent non-Hodgkin lymphoma (iNHL). PI3K inhibitors have been …

Independent real‐world application of a clinical‐grade automated prostate cancer detection system

LM da Silva, EM Pereira, PGO Salles… - The Journal of …, 2021 - Wiley Online Library
Artificial intelligence (AI)‐based systems applied to histopathology whole‐slide images have
the potential to improve patient care through mitigation of challenges posed by diagnostic …

Initial management of noncastrate advanced, recurrent, or metastatic prostate cancer: ASCO guideline update

KS Virgo, RB Rumble, R de Wit… - Journal of Clinical …, 2021 - ascopubs.org
PURPOSE Update all preceding ASCO guidelines on initial hormonal management of
noncastrate advanced, recurrent, or metastatic prostate cancer. METHODS The Expert …

Multiplatform molecular test performance in indeterminate thyroid nodules

MA Lupo, AE Walts, JW Sistrunk… - Diagnostic …, 2020 - Wiley Online Library
Background Approximately 25% of thyroid nodule fine‐needle aspirates (FNAs) have
cytology that is indeterminate for malignant disease. Accurate risk stratification of these …

Prospective role and immunotherapeutic targets of sideroflexin protein family in lung adenocarcinoma: evidence from bioinformatics validation

HH Dang, HDK Ta, TTT Nguyen, G Anuraga… - Functional & Integrative …, 2022 - Springer
As lung cancer remains the leading cause of cancer deaths globally, characterizing the
tumor molecular profiles is crucial to tailoring treatments for individuals at advanced stages …

A nanoengineered topical transmucosal cisplatin delivery system induces anti-tumor response in animal models and patients with oral cancer

M Goldberg, A Manzi, A Birdi, B Laporte… - Nature …, 2022 - nature.com
Despite therapeutic advancements, oral cavity squamous cell carcinoma (OCSCC) remains
a difficult disease to treat. Systemic platinum-based chemotherapy often leads to dose …

A phase II study of allogeneic GM-CSF–transfected pancreatic tumor vaccine (GVAX) with Ipilimumab as maintenance treatment for metastatic pancreatic cancer

AA Wu, KM Bever, WJ Ho, EJ Fertig, N Niu, L Zheng… - Clinical cancer …, 2020 - AACR
Purpose: This phase II study tested granulocyte-macrophage colony-stimulating factor (GM-
CSF)-allogeneic pancreatic tumor cells (GVAX) and ipilimumab in metastatic pancreatic …