Fluoroquinolones (FQs) are arguably among the most successful antibiotics of recent times.
They have enjoyed over 30 years of clinical usage and become essential tools in the …

Antibiotic resistance is currently one of the greatest threats to human health. Widespread
use and residues of antibiotics in humans, animals, and the environment can exert selective …

Antibacterial fluoroquinolones (FQs) are frequently used in treating infections. However, the
value of FQs is debatable due to their association with severe adverse effects (AEs). The …

Microorganisms thrive in well-organized biofilm ecosystems. Biofilm-associated cells
typically show increased resistance to antibiotics and contribute significantly to treatment …

Genetically identical bacterial cells commonly display different phenotypes. This phenotypic
heterogeneity is well known for stress responses, where it is often explained as bet hedging …

Bactericidal antibiotics can cause metabolic perturbations that contribute to antibiotic-
induced lethality. The molecular mechanism underlying these downstream effects remains …

The clinical application of quinolone antibiotics is particularly extensive. In addition to their
high efficiency in infectious diseases, the treatment process brings multiple hidden dangers …

The evolution of the class of antibacterial quinolones includes the introduction in therapy of
highly successful compounds. Although many representatives were withdrawn due to …

The emergence of serious bacterial resistance towards clinical oxacins poses a
considerable threat to global public health, necessitating the development of novel structural …

Moxifloxacin is central to treatment of multidrug-resistant tuberculosis. Effects of moxifloxacin
on the Mycobacterium tuberculosis redox state were explored to identify strategies for …