Capillary rarefaction is broadly defined as a reduction in vascular density. Capillary
rarefaction in the kidneys is thought to promote hypoxia, impair hemodynamic responses …

Within the last years, the use of stem cells (embryonic, induced pluripotent stem cells, or
hematopoietic stem cells), Progenitor cells (eg, endothelial progenitor cells), and most …

Advanced therapy medicinal products (ATMPs) offer new prospects to improve the treatment
of conditions with unmet medical needs. Kidney diseases are a current major health concern …

Damage to endothelial cells contributes to acute kidney injury (AKI) by leading to impaired
perfusion. Endothelial colony-forming cells (ECFC) are endothelial precursor cells with high …

Chronic kidney disease (CKD) affects 8–16% of the population worldwide and is
characterized by fibrotic processes. Understanding the cellular and molecular mechanisms …

To investigate T helper type 17 (Th17) cells in the setting of acute kidney injury, the gene
encoding the master regulator of Th17 cell differentiation, that is, RAR-related orphan …

Abstract Background Interleukin-17 (IL-17) antagonism in rats reduces the severity and
progression of AKI. IL-17-producing circulating T helper-17 (TH17) cells is increased in …

The diagnosis of acute kidney disease (AKI) has been examined mainly by histology,
immunohistochemistry and western blot. Though these approaches are widely accepted in …

Background Adipose stromal cells (ASC) are a form of mesenchymal stromal cells that elicit
effects primarily via secreted factors, which may have advantages for the treatment of injury …

Objective: Although stem cell therapy for renal ischemia-reperfusion injury (RIRI) has made
immense progress in animal studies, conflicting results have been reported by the …