Androgen deprivation therapy (ADT) is considered as the standard therapy for men with de
novo or recurrent metastatic prostate cancer. ADT commonly leads to initial biochemical and …

Prostate cancer (PCa) is a heterogeneous disease and ranked as the second leading cause
of cancer-related deaths in males worldwide. The global burden of PCa keeps rising …

Simple Summary Prostate cancer treatment has improved over the last 20 years; despite
this, approximately 33,000 men died from the disease in the United States in 2020. In view of …

Background In recent years, copper complexes have gradually become the focus of
potential anticancer drugs due to their available redox properties and low toxicity. In this …

Objective Curcumin, a phenolic compound extracted from turmeric rhizomes, exhibits
antitumour effects in preclinical models of tumours. However, its mechanism of action in …

Varied pathogenetic elements have been touched upon the liver fibrosis, including
inflammatory, stress, apoptosis and unfolded proteins aggregation. Magnesium …

Background Prostate cancer (PCA) is one of the leading causes of death among men, being
related to several factors, including the aging male population, like benign prostatic …

Here we report that BCL2 blocks DNA double strand break (DSB) repair via nonhomologous
end-joining (NHEJ), through sequestration of KU80 protein outside the nucleus. We find that …

Purpose The antiapoptotic B‑cell lymphoma 2 (BCL2) gene is a key player in cancer
development and progression. A functional single-nucleotide polymorphism (c.-938C> A …

Abstract Background FAM3B/PANDER is a novel cytokine-like protein that induces
apoptosis in insulin-secreting beta-cells. Since in silico data revealed that FAM3B can be …