The fight against cancer by microgravity: the multicellular spheroid as a metastasis model

D Grimm, H Schulz, M Krüger… - International Journal of …, 2022 - mdpi.com
Cancer is a disease exhibiting uncontrollable cell growth and spreading to other parts of the
organism. It is a heavy, worldwide burden for mankind with high morbidity and mortality …

Microgravity, stem cells, and cancer: A new hope for cancer treatment

U Topal, C Zamur - Stem Cells International, 2021 - Wiley Online Library
Humans are integrated with the environment where they live. Gravitational force plays an
important role in shaping the universe, lives, and even cellular biological processes …

Simulated microgravity triggers DNA damage and mitochondria-mediated apoptosis through ROS generation in human promyelocytic leukemic cells

R Singh, M Rajput, RP Singh - Mitochondrion, 2021 - Elsevier
The weightlessness or microgravity, a physical factor in space, may adversely affect the
health of the space travellers or astronauts. The knowledge about the effect of microgravity …

Simulated microgravity inhibits cell focal adhesions leading to reduced melanoma cell proliferation and metastasis via FAK/RhoA-regulated mTORC1 and AMPK …

X Tan, A Xu, T Zhao, Q Zhao, J Zhang, C Fan, Y Deng… - Scientific reports, 2018 - nature.com
Simulated microgravity (SMG) was reported to affect tumor cell proliferation and metastasis.
However, the underlying mechanism is elusive. In this study, we demonstrate that clinostat …

Simulated microgravity attenuates skin wound healing by inhibiting dermal fibroblast migration via F‐actin/YAP signaling pathway

Y Zhou, W Lv, X Peng, Y Cheng, Y Tu… - Journal of Cellular …, 2023 - Wiley Online Library
Skin and its cell components continuously subject to extrinsic and intrinsic mechanical
forces and are mechanical sensitive. Disturbed mechanical homeostasis may lead to …

Space flight and central nervous system: Friends or enemies? Challenges and opportunities for neuroscience and neuro‐oncology

G Marfia, SE Navone, L Guarnaccia… - Journal of …, 2022 - Wiley Online Library
Abstract Space environment provides many challenges to pilots, astronauts, and space
scientists, which are constantly subjected to unique conditions, including microgravity …

Simulated microgravity influences immunity-related biomarkers in lung cancer

H Baghoum, H Alahmed, M Hachim, A Senok… - International Journal of …, 2022 - mdpi.com
Microgravity is a novel strategy that may serve as a complementary tool to develop future
cancer therapies. In lung cancer, the influence of microgravity on cellular processes and the …

Breast cancer cells in microgravity: new aspects for cancer research

MZ Nassef, D Melnik, S Kopp, J Sahana… - International Journal of …, 2020 - mdpi.com
Breast cancer is the leading cause of cancer death in females. The incidence has risen
dramatically during recent decades. Dismissed as an “unsolved problem of the last century” …

Fighting thyroid cancer with microgravity research

M Krüger, D Melnik, S Kopp, C Buken… - International Journal of …, 2019 - mdpi.com
Microgravity in space or simulated by special ground-based devices provides an unusual
but unique environment to study and influence tumour cell processes. By investigating …

Apoptosis induction and alteration of cell adherence in human lung cancer cells under simulated microgravity

C Dietz, M Infanger, A Romswinkel, F Strube… - International journal of …, 2019 - mdpi.com
Background: Lung cancer cells are known to change proliferation and migration under
simulated microgravity. In this study, we sought to evaluate cell adherence, apoptosis …