The concept of central nervous system (CNS) inflammation has evolved over the last
decades. Neuroinflammation is the response of reactive CNS components to altered …

The activation of host's innate and adaptive immune systems can lead to acute and chronic
graft rejection, which seriously impacts graft survival. Thus, it is particularly significant to …

C-type lectin-like receptors (CLRs) represent a family of transmembrane pattern recognition
receptors, expressed primarily by myeloid cells. They recognize not only pathogen moieties …

As a subset of pattern recognition receptors (PRRs), C-type lectin-like receptors (CLRs) are
mainly expressed by myeloid cells as both transmembrane and soluble forms. CLRs …

C-type lectin receptors (CLRs) expressed by myeloid cells constitute a versatile family of
receptors that play a key role in innate immune recognition. Myeloid CLRs exhibit a …

The laboratory rat has been used for a long time as the model of choice in several
biomedical disciplines. Numerous inbred strains have been isolated, displaying a wide …

The C-type lectin receptor Mincle is known for its important role in innate immune cells in
recognizing pathogen and damage associated molecular patterns. Here we report a T cell …

Dysregulation of auto-reactive T cells and autoantibody-producing B cells and excessive
inflammation are responsible for the occurrence and development of autoimmune diseases …

Neuroinflammatory processes mediated by microglial activation and subsequent neuronal
damage are the hallmarks of traumatic brain injury (TBI). As an inhibitor of the macrophage …

Tubules injury and immune cell activation are the common pathogenic mechanisms in acute
kidney injury (AKI). However, the exact modes of immune cell activation following tubule …