Beyond its use as an antiepileptic drug, over time valproate has been increasingly used for
several other therapeutic applications. Among these, the antineoplastic effects of valproate …

Gastrointestinal (GI) cancers comprise a significant number of cancer cases worldwide and
contribute to a high percentage of cancer-related deaths. To improve survival rates of GI …

Human malignancies are one of the major health-related issues throughout the world and
are anticipated to rise in the future. Despite huge investments made in anticancer drug …

Background Colorectal adenoma is benign glandular tumor of colon, the precursor of
colorectal cancer. But no pharmaceutical medication is currently available to treat and …

3, 4, 5, 4'-Trans-tetramethoxystilbene (Synonyms: DMU-212) is a resveratrol analogue with
stronger antiproliferative activity and more bioavailability. However, the metabolite …

Preneoplastic high-risk lesions in the pancreas need to be differentiated from low-risk
lesions warranting surveillance and eventually surgical intervention. Imaging is used so far; …

Objectives To evaluate the efficacy of Difluoromethylornithine (DFMO) chemoprevention in
the high-risk population for colorectal cancer (CRC). Methods Meta-analysis was conducted …

Background The onset of colorectal adenomas (CRAs) is significantly associated with
colorectal cancer. The preventive effects of chemical drugs on the recurrence of CRAs have …

摘要多胺是一类普遍存在于生物体中的聚阳离子, 对生命活动发挥至关重要的作用. 在肿瘤中,
多胺稳态通常失调. 肿瘤的发生和发展过程都需要高水平的多胺, 因此, 多胺代谢是癌症治疗的 …

Purpose Recent studies suggested a protective role of metformin in the development of
colorectal cancer (CRC) and its precursors. We aimed to investigate if metformin was …