[HTML][HTML] Disease-modifying therapies and features linked to treatment response in type 1 diabetes prevention: a systematic review
Abstract Background Type 1 diabetes (T1D) results from immune-mediated destruction of
insulin-producing beta cells. Prevention efforts have focused on immune modulation and …
insulin-producing beta cells. Prevention efforts have focused on immune modulation and …
[HTML][HTML] Consensus Guidance for Monitoring Individuals With Islet Autoantibody–Positive Pre-Stage 3 Type 1 Diabetes
M Phillip, P Achenbach, A Addala… - Diabetes …, 2024 - diabetesjournals.org
Given the proven benefits of screening to reduce diabetic ketoacidosis (DKA) likelihood at
the time of stage 3 type 1 diabetes diagnosis, and emerging availability of therapy to delay …
the time of stage 3 type 1 diabetes diagnosis, and emerging availability of therapy to delay …
[HTML][HTML] The countdown to type 1 diabetes: when, how and why does the clock start?
AG Ziegler - Diabetologia, 2023 - Springer
Abstract 'The clock to type 1 diabetes has started when islet antibodies are first detected',
commented George Eisenbarth with regard to the pathogenesis of type 1 diabetes. This …
commented George Eisenbarth with regard to the pathogenesis of type 1 diabetes. This …
A phase 2 randomized trial with autologous polyclonal expanded regulatory T cells in children with new-onset type 1 diabetes
C Bender, AE Wiedeman, A Hu… - Science Translational …, 2024 - science.org
CD4+ CD25hiCD127lo/− FOXP3+ regulatory T cells (Tregs) play a key role in preventing
autoimmunity. In autoimmune type 1 diabetes (T1D), adoptive transfer of autologous …
autoimmunity. In autoimmune type 1 diabetes (T1D), adoptive transfer of autologous …
[HTML][HTML] Development of an immunoassay for the simultaneous detection of GADA and ZnT8A in autoimmune diabetes using a ZnT8/GAD65 chimeric molecule
A Trabucchi, SS Bombicino, AV Sabljic… - Frontiers in …, 2023 - frontiersin.org
Introduction The combined presence of autoantibodies to the 65 kDa isoform of glutamic
acid decarboxylase (GADA) and to the islet-specific cation efflux transporter ZnT8 (ZnT8A) in …
acid decarboxylase (GADA) and to the islet-specific cation efflux transporter ZnT8 (ZnT8A) in …
[HTML][HTML] Islet autoantibodies as precision diagnostic tools to characterize heterogeneity in type 1 diabetes: a systematic review
Background Islet autoantibodies form the foundation for type 1 diabetes (T1D) diagnosis and
staging, but heterogeneity exists in T1D development and presentation. We hypothesized …
staging, but heterogeneity exists in T1D development and presentation. We hypothesized …
Improved Specificity of Glutamate Decarboxylase 65 Autoantibody Measurement Using Luciferase-Based Immunoprecipitation System Assays
RC Wyatt, SL Grace, C Brigatti, I Marzinotto… - Diabetes, 2024 - Am Diabetes Assoc
Autoantibodies to glutamate decarboxylase (GADA) are widely used in the prediction and
classification of type 1 diabetes. GADA radiobinding assays (RBAs) using N-terminally …
classification of type 1 diabetes. GADA radiobinding assays (RBAs) using N-terminally …
High Rate of Islets Autoimmunity in Pediatric Patients with Index Admission of Acute Pancreatitis
JD Tatum, L Hornung, MD Bellin, DA Elder… - Pediatric …, 2023 - Wiley Online Library
Introduction. The underlying pathophysiology of diabetes mellitus after acute pancreatitis is
unknown and overall risk of developing diabetes postacute pancreatitis in children is …
unknown and overall risk of developing diabetes postacute pancreatitis in children is …
Type 1 Diabetes Prevention: a systematic review of studies testing disease-modifying therapies and features linked to treatment response
Abstract Background Type 1 diabetes (T1D) results from immune-mediated destruction of
insulin-producing beta cells. Efforts to prevent T1D have focused on modulating immune …
insulin-producing beta cells. Efforts to prevent T1D have focused on modulating immune …
Precision diagnostics: using islet autoantibodies to characterize heterogeneity in type 1 diabetes
Background Heterogeneity exists in type 1 diabetes (T1D) development and presentation.
Islet autoantibodies form the foundation for T1D diagnostic and staging efforts. We …
Islet autoantibodies form the foundation for T1D diagnostic and staging efforts. We …