Gastro-oesophageal reflux disease

R Fass, GE Boeckxstaens, H El-Serag… - Nature reviews Disease …, 2021 - nature.com
Gastro-oesophageal reflux disease (GERD) is a common disorder in adults and children.
The global prevalence of GERD is high and increasing. Non-erosive reflux disease is the …

potassium‐competitive acid blockers for the treatment of acid‐related disorders

Y Abdel‐Aziz, DC Metz… - Alimentary Pharmacology …, 2021 - Wiley Online Library
Background Potassium‐competitive acid blockers (P‐CABs) are a novel group of acid‐
suppressing medicines for the management of acid‐related disorders. Aims To review …

Vonoprazan fumarate, a novel potassium-competitive acid blocker, in the management of gastroesophageal reflux disease: safety and clinical evidence to date

K Sugano - Therapeutic advances in gastroenterology, 2018 - journals.sagepub.com
Potassium-competitive acid blocker (P-CAB) is a class of drug that competitively blocks the
potassium-binding site of H+, K+-adenosine triphosphate (ATP) ase. Although the history of …

Gastroesophageal reflux disease

R Fass - New England Journal of Medicine, 2022 - Mass Medical Soc
Key Clinical Points Gastroesophageal Reflux Disease Patients with heartburn and
symptoms such as dysphagia, odynophagia, weight loss, anorexia, gastrointestinal …

Evidence-based clinical practice guidelines for gastroesophageal reflux disease 2021

K Iwakiri, Y Fujiwara, N Manabe, E Ihara… - Journal of …, 2022 - Springer
In Japan, with the increasing prevalence of gastroesophageal reflux disease (GERD) and
growing public interest, the Japanese Society of Gastroenterology issued Evidence-based …

Randomised phase 3 trial: tegoprazan, a novel potassium‐competitive acid blocker, vs. esomeprazole in patients with erosive oesophagitis

KJ Lee, BK Son, GH Kim, HK Jung… - Alimentary …, 2019 - Wiley Online Library
Background Tegoprazan is a novel potassium‐competitive acid blocker that has a fast onset
of action and can control gastric pH for a prolonged period, which could offer clinical benefit …

Direct comparison of the efficacy and safety of vonoprazan versus proton-pump inhibitors for gastroesophageal reflux disease: a systematic review and meta-analysis

Y Cheng, J Liu, X Tan, Y Dai, C Xie, X Li, Q Lu… - Digestive Diseases and …, 2021 - Springer
Background Gastroesophageal reflux disease (GERD) is a common disorder, and is
typically treated with proton-pump inhibitors (PPIs) as the recommended first-line therapy …

Randomised clinical trial: comparison of tegoprazan and placebo in non‐erosive reflux disease

SH Kim, KB Cho, HJ Chun, SW Lee… - Alimentary …, 2021 - Wiley Online Library
Background Tegoprazan is a novel, fast‐and long‐acting potassium‐competitive acid
blocker that suppresses gastric acid secretion, which could benefit patients with non‐erosive …

AGA clinical practice update on integrating potassium-competitive acid blockers into clinical practice: expert review

A Patel, L Laine, P Moayyedi, J Wu - Gastroenterology, 2024 - Elsevier
Description The purpose of this American Gastroenterological Association (AGA) Institute
Clinical Practice Update (CPU) is to summarize the available evidence and offer expert Best …

Novel therapies for gastroesophageal reflux disease: beyond proton pump inhibitors

F Shibli, Y Kitayama, R Fass - Current gastroenterology reports, 2020 - Springer
Abstract Purpose of Review Despite the many areas of unmet needs in gastroesophageal
reflux disease (GERD), proton pump inhibitors (PPIs) remain the cornerstone of medical …