When mycophenolic acid (MPA) was originally marketed for immunosuppressive therapy,
fixed doses were recommended by the manufacturer. Awareness of the potential for a more …

Immunosuppressive agents are commonly used in the nephrologist's practice in the
treatment of autoimmune and immune-mediated diseases and transplantation, and they are …

Abstract Model-informed precision dosing (MIPD) stands as a significant development in
personalized medicine to tailor drug dosing to individual patient characteristics. MIPD moves …

The severe side effects of long-term corticosteroid or cyclosporin A (CsA) therapy complicate
the treatment of children with frequently relapsing steroid-sensitive nephrotic syndrome (FR …

Therapeutic drug monitoring (TDM) for tacrolimus (Tac) is universally applied. However, the
concentration–effect relationship for Tac is poorly defined. This study investigated whether …

Monitoring immunosuppressive drugs (ISDs) in blood or plasma is still a key therapeutic
drug monitoring (TDM) application in clinical settings. Narrow target ranges and severe side …

Therapeutic drug monitoring (TDM) of immunosuppressive drugs (ISDs) with a narrow
therapeutic index is an increasingly popular tool for minimizing drug toxicity while …

The replication kinetics of nonpathogenic anelloviruses belonging to the Alphatorquevirus
genus (such as torque teno virus) might reflect the overall state of posttransplant …

The immunosuppressive agent mycophenolate is used extensively in kidney transplantation,
yet dosing strategy applied varies markedly from fixed dosing (“one-dose-fits-all”), to …

This article summarizes part of a consensus meeting about mycophenolate (MPA)
therapeutic drug monitoring held in Rome under the auspices of The Transplantation …