There is a continuing rise in the occurrence of multidrug-resistant bacterial infections.
Antibiotic resistance to currently available antibiotics has become a global health issue …

Similar to its eukaryotic counterpart, the prokaryotic cytoskeleton is essential for the
structural and mechanical properties of bacterial cells. The essential protein FtsZ is a central …

The antimicrobial resistance crisis requires the introduction of novel antibiotics. The use of
conventional broad-spectrum compounds selects for resistance in off-target pathogens and …

Several phenyl substituted naphthalenes and isoquinolines have been identified as
antibacterial agents that inhibit FtsZ-Zing formation. In the present study we evaluated the …

With the emergence of multidrug-resistant bacterial strains, there is a dire need for new drug
targets for antibacterial drug discovery and development. Filamentous temperature sensitive …

FtsZ is the key protein of bacterial cell division and an emergent target for new antibiotics. It
is a filament-forming GTPase and a structural homologue of eukaryotic tubulin. A number of …

In recent years, the rise of antibiotic resistance has become a primary health problem. With
the emergence of bacterial resistance, the need to explore and develop novel antibacterial …

Tuberculosis (TB) is the fastest spreading infectious disease and one of the top ten diseases
that kill millions of people annually. The rapid spread of a multidrug‐resistant strain of …

The prevalence of pulmonary infections due to nontuberculous mycobacteria such as
Mycobacterium abscessus has been increasing and surpassing tuberculosis (TB) in some …

FtsZ, an essential protein for bacterial cell division, is a highly promising therapeutic target,
especially for the discovery and development of new-generation anti-TB agents. Following …