Neurotrophin Trk receptors: new targets for cancer therapy
J Meldolesi - … of physiology, biochemistry and pharmacology Vol …, 2018 - Springer
In the last few years, exciting reports have emerged regarding the role of the two types of
neurotrophin receptors, p75 NTR and Trks, not only in neurons, where they were …
neurotrophin receptors, p75 NTR and Trks, not only in neurons, where they were …
Design, synthesis and biological evaluation of 3-substituted-2-oxindole hybrid derivatives as novel anticancer agents
The 2-oxindole nucleus is the central core to develop new anticancer agents and its
substitution at the 3-position can effect antitumor activity. Utilizing a pharmacophore …
substitution at the 3-position can effect antitumor activity. Utilizing a pharmacophore …
Identification of natural compounds against neurodegenerative diseases using in silico techniques
The aim of this study was to identify new potentially active compounds for three protein
targets, tropomyosin receptor kinase A (TrkA), N-methyl-d-aspartate (NMDA) receptor, and …
targets, tropomyosin receptor kinase A (TrkA), N-methyl-d-aspartate (NMDA) receptor, and …
Classification models for predicting the bioactivity of pan-TRK inhibitors and SAR analysis
X Zhao, Y Kong, Y Ji, X Xin, L Chen, G Chen, C Yu - Molecular Diversity, 2023 - Springer
Tropomyosin receptor kinases (TRKs) are important broad-spectrum anticancer targets. The
oncogenic rearrangement of the NTRK gene disrupts the extracellular structural domain and …
oncogenic rearrangement of the NTRK gene disrupts the extracellular structural domain and …
Regioselective C–H sulfenylation of N-sulfonyl protected 7-azaindoles promoted by TBAI: a rapid synthesis of 3-thio-7-azaindoles
J Hu, X Ji, S Hao, M Zhao, M Lai, T Ren, G Xi, E Wang… - RSC …, 2020 - pubs.rsc.org
This paper describes the regioselective C-3 sulfenylation of N-sulfonyl protected 7-
azaindoles with sulfonyl chlorides. In this transformation, dual roles of TBAI serving as both …
azaindoles with sulfonyl chlorides. In this transformation, dual roles of TBAI serving as both …