This review deals with conformational analysis in small organic molecules, and describes
the stereoelectronic interactions responsible for conformational stability. Conformational …

Ligand-based fluorine NMR screening has gained popularity in drug discovery projects
during the past decade and has become a powerful methodology to produce high quality …

Herein, we report on a transparent, water-stable, high oxygen barrier packaging film made
from a combination of cellulose nanofiber (CNF) and a fluoropolymer (FP) coating …

It is known that strong hydrogen‐bonding interactions play an important role in many
chemical and biological systems. However, weak or very weak hydrogen bonds, which are …

Modulation of the H-bond basicity (p K HB) of various functional groups (FGs) by attaching
fluorine functions and its impact on lipophilicity and bioisosterism considerations are …

A study was made of X—H⋯ F—C interactions (X= N or O) in small-molecule crystal
structures. It was primarily based on 6728 structures containing X—H and C—F and no atom …

The propensity of organic fluorine acting as a weak hydrogen bond acceptor (HBA) in
intermolecular and intramolecular interactions has been the subject of many experimental …

Rational modulations of molecular interactions are of significant importance in compound
properties optimization. We have previously shown that fluorination of conformationally rigid …

Alzheimer's disease is the most common neurodegenerative disease and currently poses a
significant socioeconomic problem. This study describes the uses of computer-aided drug …

We describe, for the first time, two protocols for direct difluoromethylation of unactivated alkyl
bromides and iodides. Reactions of alkyl iodides with TMSCF2H were mediated by a copper …