Chemical mechanisms of nanoparticle radiosensitization and radioprotection: a review of structure-function relationships influencing reactive oxygen species

D Howard, S Sebastian, QVC Le, B Thierry… - International Journal of …, 2020 - mdpi.com
Metal nanoparticles are of increasing interest with respect to radiosensitization. The physical
mechanisms of dose enhancement from X-rays interacting with nanoparticles has been well …

The MTT assay: utility, limitations, pitfalls, and interpretation in bulk and single-cell analysis

M Ghasemi, T Turnbull, S Sebastian… - International journal of …, 2021 - mdpi.com
The MTT assay for cellular metabolic activity is almost ubiquitous to studies of cell toxicity;
however, it is commonly applied and interpreted erroneously. We investigated the …

Mechanisms of nanoparticle radiosensitization

I Kempson - Wiley Interdisciplinary Reviews: Nanomedicine …, 2021 - Wiley Online Library
Metal‐based nanoparticles applied to potentiating the effects of radiotherapy have drawn
significant attention from the research community and are now available clinically. By …

Oxidative damage to mitochondria enhanced by ionising radiation and gold nanoparticles in cancer cells

F Tabatabaie, R Franich, B Feltis, M Geso - International journal of …, 2022 - mdpi.com
Gold nanoparticles (AuNP) can increase the efficacy of radiation therapy by sensitising
tumor cells to radiation damage. When used in combination with radiation, AuNPs enhance …

[HTML][HTML] Accumulation of nanoplastics in human cells as visualized and quantified by hyperspectral imaging with enhanced dark-field microscopy

HJ Zhang, HR Zhou, W Pan, C Wang, YY Liu… - Environment …, 2023 - Elsevier
Nanoplastic (NP) pollution is receiving increasing attention regarding its potential effects on
human health. The identification and quantification of intracellular NPs are prerequisites for …

Quantification of monodisperse and biocompatible gold nanoparticles by single-particle ICP-MS

AN Frickenstein, S Mukherjee, T Harcourt, Y He… - Analytical and …, 2023 - Springer
Bioanalytical and biomedical applications often require nanoparticles that exhibit narrow
size distributions and biocompatibility. Here, we demonstrate how different synthesis …

Kinetic Effects of Transferrin-Conjugated Gold Nanoparticles on the Antioxidant Glutathione-Thioredoxin Pathway

S Sebastian, MK Hoffmann, D Howard, C Young… - Antioxidants, 2023 - mdpi.com
Nanoparticle-based therapeutics are being clinically translated for treating cancer. Even
when thought to be biocompatible, nanoparticles are being increasingly identified as …

Cell Size as a Primary Determinant in Targeted Nanoparticle Uptake

D Howard, T Turnbull, DJ Paterson… - ACS Applied Bio …, 2022 - ACS Publications
Nanoparticle (NP) internalization by cells is complex, highly heterogeneous, and
fundamentally important for nanomedicine. We report powerful probabilistic statistics from …

Predictive modeling of hypoxic head and neck cancers during fractionated radiotherapy with gold nanoparticle radiosensitization

M Huynh, I Kempson, E Bezak, W Phillips - Medical Physics, 2021 - Wiley Online Library
Purpose Intrinsic radioresistance and increased proliferation rates in head and neck cancers
(HNCs) are associated with negative radiotherapy (RT) treatment responses. The use of …

On predicting heterogeneity in nanoparticle dosage

CV Dowling, PM Cevaal, M Faria, ST Johnston - Mathematical Biosciences, 2022 - Elsevier
Nanoparticles are increasingly employed as a vehicle for the targeted delivery of
therapeutics to specific cell types. However, much remains to be discovered about the …