The discovery of the sensory nature of the carotid body dates back to the beginning of the
20th century. Following these seminal discoveries, research into carotid body mechanisms …

The respiratory response to hypoxia in mammals develops from an inhibition of breathing
movements in utero into a sustained increase in ventilation in the adult. This ventilatory …

▪ Abstract O2 sensing is a fundamental biological process necessary for adaptation of living
organisms to variable habitats and physiological situations. Cellular responses to hypoxia …

In this review, the maturational changes occurring in the mammalian respiratory network
from fetal to adult ages are analyzed. Most of the data presented were obtained on rodents …

The ability to sense and respond to oxygen deprivation is required for survival; thus,
understanding the mechanisms by which changes in oxygen are linked to cell viability and …

O2 sensing is of critical importance for cell survival and adaptation of living organisms to
changing environments or physiological conditions. O2-sensitive ion channels are major …

Hypoxic chemotransduction in the carotid body requires release of excitatory transmitters
from type I cells that activate afferent sensory neurones. Transmitter release is dependent on …

We have developed a thin-slice preparation of whole rat carotid body that allows us to
perform patch-clamp recording of membrane ionic currents and to monitor catecholamine …

Any general model of respiratory control must explain a puzzling array of breathing patterns
that are observed during the course of a lifetime. Particular challenges are to understand …

Regulation of breathing is critical to our capacity to accommodate deficits in oxygen
availability and demand during, for example, sleep and ascent to altitude. It is generally …