Research in cellular mechanotransduction often focuses on how extracellular physical
forces are converted into chemical signals at the cell surface. However, mechanical forces …

The giant protein titin forms a unique filament network in cardiomyocytes, which engages in
both mechanical and signaling functions of the heart. TTN, which encodes titin, is also a …

Cancers arise owing to mutations in a subset of genes that confer growth advantage. The
availability of the human genome sequence led us to propose that systematic resequencing …

During cell migration, the movement of the nucleus must be coordinated with the
cytoskeletal dynamics at the leading edge and trailing end, and, as a result, undergoes …

The 364 exon TTN gene encodes titin (TTN), the largest known protein, which plays key
structural, developmental, mechanical, and regulatory roles in cardiac and skeletal muscles …

Few genes have generated as much recent interest as LMNA, LMNB1 and LMNB2, which
encode the components of the nuclear lamina. Over 180 mutations in these genes are …

In the cytosol, actin polymers, intermediate filaments and microtubules can anchor to cell
surface adhesions and interlink to form intricate networks. This cytoskeleton is anchored to …

Mechanical stress signals transmitted through the heart walls during hemodynamic loading
are sensed by the myocytes, which respond with changes in contractile performance and …

A-type lamins (lamins A and C), encoded by the LMNA gene, are major protein constituents
of the mammalian nuclear lamina, a complex structure that acts as a scaffold for protein …

The nucleus is the distinguishing feature of eukaryotic cells. Until recently, it was often
considered simply as a unique compartment containing the genetic information of the cell …