Therapeutic strategies for COVID-19: progress and lessons learned
G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
Nanobodies: Robust miniprotein binders in biomedicine
Variable domains of heavy chain-only antibodies (VHH), also known as nanobodies (Nbs),
are monomeric antigen-binding domains derived from the camelid heavy chain-only …
are monomeric antigen-binding domains derived from the camelid heavy chain-only …
Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escape
The emergence of SARS-CoV-2 variants threatens current vaccines and therapeutic
antibodies and urgently demands powerful new therapeutics that can resist viral escape. We …
antibodies and urgently demands powerful new therapeutics that can resist viral escape. We …
A Glycosylated RBD protein induces enhanced neutralizing antibodies against omicron and other variants with improved protection against SARS-CoV-2 infection
ABSTRACT SARS-CoV-2 has mutated frequently since its first emergence in 2019.
Numerous variants, including the currently emerging Omicron variant, have demonstrated …
Numerous variants, including the currently emerging Omicron variant, have demonstrated …
Recent advances in nanotechnology-based COVID-19 vaccines and therapeutic antibodies
COVID-19 has caused a global pandemic and millions of deaths. It is imperative to develop
effective countermeasures against the causative viral agent, SARS-CoV-2 and its many …
effective countermeasures against the causative viral agent, SARS-CoV-2 and its many …
Mechanisms of SARS-CoV-2 neutralization by shark variable new antigen receptors elucidated through X-ray crystallography
Abstract Single-domain Variable New Antigen Receptors (VNARs) from the immune system
of sharks are the smallest naturally occurring binding domains found in nature. Possessing …
of sharks are the smallest naturally occurring binding domains found in nature. Possessing …
Correlation between the binding affinity and the conformational entropy of nanobody SARS-CoV-2 spike protein complexes
H Mikolajek, M Weckener… - Proceedings of the …, 2022 - National Acad Sciences
Camelid single-domain antibodies, also known as nanobodies, can be readily isolated from
naïve libraries for specific targets but often bind too weakly to their targets to be immediately …
naïve libraries for specific targets but often bind too weakly to their targets to be immediately …
Arsenal of nanobodies shows broad-spectrum neutralization against SARS-CoV-2 variants of concern in vitro and in vivo in hamster models
Nanobodies offer several potential advantages over mAbs for the control of SARS-CoV-2.
Their ability to access cryptic epitopes conserved across SARS-CoV-2 variants of concern …
Their ability to access cryptic epitopes conserved across SARS-CoV-2 variants of concern …
[PDF][PDF] Superimmunity by pan-sarbecovirus nanobodies
Vaccine boosters and infection can facilitate the development of SARS-CoV-2 antibodies
with improved potency and breadth. Here, we observe superimmunity in a camelid …
with improved potency and breadth. Here, we observe superimmunity in a camelid …
RBD-mRNA vaccine induces broadly neutralizing antibodies against Omicron and multiple other variants and protects mice from SARS-CoV-2 challenge
Multiple SARS-CoV-2 variants are identified with higher rates of transmissibility or greater
disease severity. Particularly, recent emergence of Omicron variant with rapid human-to …
disease severity. Particularly, recent emergence of Omicron variant with rapid human-to …