[HTML][HTML] Inflammaging and Brain Aging

MC Jurcau, A Jurcau, A Cristian, VO Hogea… - International Journal of …, 2024 - mdpi.com
Progress made by the medical community in increasing lifespans comes with the costs of
increasing the incidence and prevalence of age-related diseases, neurodegenerative ones …

Microbiota, Tryptophan and aryl hydrocarbon receptors as the target triad in Parkinson's disease—A narrative review

P Iwaniak, M Owe-Larsson, EM Urbańska - International Journal of …, 2024 - mdpi.com
In the era of a steadily increasing lifespan, neurodegenerative diseases among the elderly
present a significant therapeutic and socio-economic challenge. A properly balanced diet …

[HTML][HTML] Exercise, Neuroprotective Exerkines, and Parkinson's Disease: A Narrative Review

AK Mitchell, RR Bliss, FC Church - Biomolecules, 2024 - pmc.ncbi.nlm.nih.gov
Parkinson's disease (PD) is a prevalent neurodegenerative disease in which treatment often
includes an exercise regimen. Exercise is neuroprotective in animal models of PD, and …

[HTML][HTML] Iron toxicity, ferroptosis and microbiota in Parkinson's disease: Implications for novel targets

FV Carvalho, HE Landis, B Getachew… - Advances in …, 2024 - ncbi.nlm.nih.gov
Parkinson's Disease (PD) is a progressive neurodegenerative disease characterized by loss
of dopaminergic neurons in substantia nigra pars compacta (SNpc). Iron (Fe)-dependent …

[HTML][HTML] The quest for eternal youth: hallmarks of aging and rejuvenating therapeutic strategies

VS Nunkoo, A Cristian, A Jurcau, RG Diaconu… - Biomedicines, 2024 - mdpi.com
The impressive achievements made in the last century in extending the lifespan have led to
a significant growth rate of elderly individuals in populations across the world and an …

[HTML][HTML] Oxidative stress in the pathogenesis of neurodegenerative diseases

MC Jurcau, A Jurcau, RG Diaconu - Stresses, 2024 - mdpi.com
Neurodegenerative diseases are devastating conditions with a rising incidence and
prevalence due to the aging of the population for which we currently do not have efficient …

[HTML][HTML] A Systematic Review of Sporadic Creutzfeldt-Jakob Disease: Pathogenesis, Diagnosis, and Therapeutic Attempts

MC Jurcau, A Jurcau, RG Diaconu, VO Hogea… - Neurology …, 2024 - mdpi.com
Creutzfeldt-Jakob disease is a rare neurodegenerative and invariably fatal disease with a
fulminant course once the first clinical symptoms emerge. Its incidence appears to be rising …

The Impact of Intestinal Microbiota and Toll-like Receptor 2 Signaling on α-Synuclein Pathology in Nontransgenic Mice Injected with α-Synuclein Preformed Fibrils

Y Koyanagi, M Kassai, H Yoneyama - Microorganisms, 2024 - mdpi.com
Intestinal microbiota and Toll-like receptor 2 (TLR2), which can bind lipoteichoic acid
produced by microbiota, might contribute to the pathogenesis of Parkinson's disease (PD) …

[HTML][HTML] Psychometric Properties of Jebsen Taylor Hand Function Test in an Italian Population with Parkinson's Disease

G Galeoto, A Berardi, R Simeon, F Panuccio… - Healthcare, 2024 - mdpi.com
Background: Assessment of upper limb function is critical in the rehabilitation process of
people with Parkinson's Disease (PD), and universally validated outcome measures are …

Sentinels of neuroinflammation: the crucial role of myeloid cells in the pathogenesis of gliomas and neurodegenerative diseases

B Cómitre-Mariano, G Vellila-Alonso… - Journal of …, 2024 - Springer
The inflammatory processes that drive pathologies of the central nervous system (CNS) are
complex and involve significant contributions from the immune system, particularly myeloid …