The past two centuries have witnessed an unprecedented rise in human life expectancy.
Sustaining longer lives with reduced periods of disability will require an understanding of the …

Several studies on the genetics of longevity have been reviewed in this paper. The results
show that, despite efforts and new technologies, only two genes, APOE and FOXO3A …

Human longevity is heritable, but genome-wide association (GWA) studies have had limited
success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity …

Although recent studies have revealed the association between the human microbiome
especially gut microbiota and longevity, their causality remains unclear. Here, we assess the …

A better understanding of the biological and environmental variables that contribute to
exceptional longevity has the potential to inform the treatment of geriatric diseases and help …

Aging is a complex process indicated by low energy levels, declined physiological activity,
stress induced loss of homeostasis leading to the risk of diseases and mortality. Recent …

The current increase in lifespan without an equivalent increase in healthspan poses a grave
challenge to the healthcare system and a severe burden on society. However, some …

Abstract Background The American Heart Association introduced the Life's Simple 7
initiative to improve cardiovascular health by modifying cardiovascular risk factors and …

Like other infectious diseases, COVID-19 shows a clinical outcome enormously variable,
ranging from asymptomatic to lethal. In Italy, like in other countries, old male individuals, with …

There is growing interest in studying the genetic contributions to longevity, but limited
relevant genes have been identified. In this study, we performed a genetic association study …