Homocysteine (Hcy) is a sulfur-containing non-proteinogenic amino acid formed during the
metabolism of the essential amino acid methionine. Hcy is considered a risk factor for …

Hydrogen sulfide can signal through 3 distinct mechanisms: 1) reduction and/or direct
binding of metalloprotein heme centers, 2) serving as a potent antioxidant through reactive …

Hydrogen sulfide has been recently identified as the third biological gasotransmitter, along
with the more well studied nitric oxide (NO) and carbon monoxide (CO). Intensive studies on …

Using a novel rat model of Down syndrome (DS), the functional role of the cystathionine-β-
synthase (CBS)/hydrogen sulfide (H 2 S) pathway was investigated on the pathogenesis of …

The trans-sulfuration enzyme cystathionine-β-synthase (CBS) and its product hydrogen
sulfide (H2S) are aberrantly upregulated in colorectal cancers, where they contribute to …

Cardiovascular disease is the main cause of death worldwide, but its pathogenesis is not yet
clear. Hydrogen sulfide (H2S) is considered to be the third most important endogenous …

The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing and approximately
25% of the global population may have NAFLD. NAFLD is associated with obesity and …

Abstract Introduction Hydrogen sulfide (H 2 S) was revealed to inhibit aortic valve
calcification and inflammation was implicated in the pathogenesis of calcific aortic valve …

Hyperhomocysteinemia (HHcy) exerts a wide range of biological effects and is associated
with a number of diseases, including cardiovascular disease, dementia, neural tube defects …

While the role of hyperhomocysteinemia in cardiovascular pathogenesis continuously draws
attention, deficiency of hydrogen sulfide (H2S) has been growingly implicated in …