Several promising strategies based on combining or cycling different antibiotics have been
proposed to increase efficacy and counteract resistance evolution, but we still lack a deep …

Lactic acid bacteria (LAB) are important starter, commensal, or pathogenic microorganisms.
The stress physiology of LAB has been studied in depth for over 2 decades, fueled mostly by …

Lipoteichoic acid (LTA) is an important cell wall polymer found in gram-positive bacteria.
Although the exact role of LTA is unknown, mutants display significant growth and …

Bacteria encounter a myriad of stresses in their natural environments, including, for
pathogens, their hosts. These stresses elicit a variety of specific and highly regulated …

Background Daptomycin is a lipopeptide with bactericidal activity that acts on the cell
membrane of enterococci and is often used off-label to treat patients infected with …

The global public health threat of antimicrobial resistance has led the scientific community to
highly engage into research on alternative strategies to the traditional small molecule …

Antimicrobial peptides (AMPs) are a key component of the host's innate immune system,
targeting invasive and colonizing bacteria. For successful survival and colonization of the …

Two-component regulatory systems (TCSs) are a major mechanism by which bacteria sense
and respond to changes in their environment. TCSs typically consist of two proteins that …

Since its discovery in 1924 by J Clarke, Streptococcus mutans has been the focus of
rigorous research efforts due to its involvement in caries initiation and progression. Its ability …

Within a given microbial population, a small subpopulation known as dormant persister cells
exists. This persistence property ensures the survival of the population as a whole in the …