The roles of APOBEC-mediated RNA editing in SARS-CoV-2 mutations, replication and fitness

K Kim, P Calabrese, S Wang, C Qin, Y Rao, P Feng… - Scientific Reports, 2022 - nature.com
During COVID-19 pandemic, mutations of SARS-CoV-2 produce new strains that can be
more infectious or evade vaccines. Viral RNA mutations can arise from misincorporation by …

Can the SARS-CoV-2 omicron variant confer natural immunity against COVID-19?

AH Abas, S Marfuah, R Idroes, D Kusumawaty… - Molecules, 2022 - mdpi.com
The coronavirus disease 2019 (COVID-19) pandemic is still ongoing, with no signs of
abatement in sight. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Population genetic models for the spatial spread of adaptive variants: A review in light of SARS-CoV-2 evolution

MC Steiner, J Novembre - PLoS Genetics, 2022 - journals.plos.org
Theoretical population genetics has long studied the arrival and geographic spread of
adaptive variants through the analysis of mathematical models of dispersal and natural …

The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection

H Goldswain, X Dong, R Penrice-Randal, M Alruwaili… - Genome biology, 2023 - Springer
Background The mutational landscape of SARS-CoV-2 varies at the dominant viral genome
sequence and minor genomic variant population. During the COVID-19 pandemic, an early …

Microfluidic point-of-care device for detection of early strains and B. 1.1. 7 variant of SARS-CoV-2 virus

J Lim, R Stavins, V Kindratenko, J Baek, L Wang… - Lab on a Chip, 2022 - pubs.rsc.org
Since the beginning of the COVID-19 pandemic, several mutations of the SARS-CoV-2 virus
have emerged. Current gold standard detection methods for detecting the virus and its …

Detection of a-to-i rna editing in sars-cov-2

E Picardi, L Mansi, G Pesole - Genes, 2021 - mdpi.com
ADAR1-mediated deamination of adenosines in long double-stranded RNAs plays an
important role in modulating the innate immune response. However, recent investigations …

Commentary on “Poor evidence for host-dependent regular RNA editing in the transcriptome of SARS-CoV-2”

F Martignano, S Di Giorgio, G Mattiuz… - Journal of Applied …, 2022 - Springer
Abstract Analysis of the SARS-CoV-2 transcriptome has revealed a background of low-
frequency intra-host genetic changes with a strong bias towards transitions. A similar pattern …

The first three waves of the Covid-19 pandemic hint at a limited genetic repertoire for SARS-CoV-2

TM Wassenaar, V Wanchai, G Buzard… - FEMS Microbiology …, 2022 - academic.oup.com
The genomic diversity of SARS-CoV-2 is the result of a relatively low level of spontaneous
mutations introduced during viral replication. With millions of SARS-CoV-2 genome …

Progress in the Diagnosis and Treatment of COVID-19 in Children: A Review

L Wang, G Li, C Yuan, Y Yang, G Ling… - … Journal of General …, 2021 - Taylor & Francis
Abstract Coronavirus disease 2019 (COVID-19) has been circulating in many countries
around the world, characterized by long incubation period, strong infectivity, strong …

[HTML][HTML] Seasonal effects decouple SARS-CoV-2 haplotypes worldwide

T Tomaszewski, MA Ali, K Caetano-Anollés… - …, 2023 - ncbi.nlm.nih.gov
Background: Variants of concern (VOCs) have been replacing each other during the still
rampant COVID-19 pandemic. As a result, SARS-CoV-2 populations have evolved …