This review focuses on the multiple and reciprocal relationships that exist between oxidative
stress, hyperglycemia and diabetes and related metabolic disorders. Human metabolism …

Carbon monoxide (CO) poisoning affects 50,000 people a year in the United States. The
clinical presentation runs a spectrum, ranging from headache and dizziness to coma and …

Ferroptosis is a form of oxidative cell death and has become a chemotherapeutic target for
cancer treatment. BAY 11–7085 (BAY), which is a well-known IκBα inhibitor, suppressed …

Heme-oxygenase is the enzyme responsible for degradation of endogenous iron
protoporphyirin heme; it catalyzes the reaction's rate-limiting step, resulting in the release of …

Heme oxygenase catalyzes the rate-limiting step in heme degradation in order to generate
biliverdin, carbon monoxide (CO), and iron. The inducible form of the enzyme, heme …

Iron is an essential but potentially hazardous biometal. Mammalian cells require sufficient
amounts of iron to satisfy metabolic needs or to accomplish specialized functions. Iron is …

It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia
causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last …

The heme oxygenase-1 (HO-1) enzyme system remains an attractive therapeutic target for
the treatment of inflammatory conditions. HO-1, a cellular stress protein, serves a vital …

Heme (iron-protoporphyrin IX) is an essential co-factor involved in multiple biological
processes: oxygen transport and storage, electron transfer, drug and steroid metabolism …

In contrast to their role in cell types with higher energy demands, mitochondria in endothelial
cells primarily function in signaling cellular responses to environmental cues. This article …