Phytochemicals belonging to the group of alkaloids are signature specialized metabolites
endowed with countless biological activities. Plants are armored with these naturally …

The development of new strategies for synthesis of medium-sized heterocycles has
remained a highly attractive but challenging proposition. In the last few years, the application …

Curcumin, a dietary spice from turmeric, is known to be anti-inflammatory, anticarcinogenic,
and antithrombotic. Here, we studied the mechanism of the antiplatelet action of curcumin …

Sanguinaria canadensis, also known as bloodroot, is a traditional medicine used by Native
Americans to treat a diverse range of clinical conditions. The plants rhizome contains …

Through pharmacological activity research, an increasing number of natural products and
their derivatives are being recognized for their therapeutic value. In recent years, studies …

Solid–liquid extraction was performed in a batch extractor, from aerial parts of Fumaria
officinalis, in order to obtain an extract containing protopine. This study relates the influences …

We investigated the anti-inflammatory activity of protopine (PTP) and sought to determine its
mechanism of action in LPS-stimulated BV2 cells and a carrageenan (CA)-induced mouse …

Calcium and lipid peroxidation play important roles in oxidative stress-induced cellular injury
and apoptosis, which ultimately cause cell death. In this study we examined whether …

Ethnopharmacological relevance Traditional pharmacopeias have been developed by
multiple cultures and evaluated for efficacy and safety through both historical/empirical …

The tumor suppressor p53 plays essential roles in cellular protection mechanisms against a
variety of stress stimuli and its activation induces apoptosis or autophagy in certain cancer …