The p53 pathway has been extensively studied for its role in carcinogenesis. Disruption of the pathway occurs in more than half of all cancers, often leading to a worse prognosis for …
CP Jia, XQ Zhong, B Hua, MY Liu, FX Jing… - Biosensors and …, 2009 - Elsevier
Highly sensitive protein detection method based on nanoparticles and enzyme-linked immunosorbent assays (ELISAs), named Nano-ELISA, was introduced. In this method, the …
L Liu, C Wu, Y Wang, R Zhong, S Duan, S Wei… - Journal of Thoracic …, 2011 - Elsevier
Introduction Multiple biologically relevant polymorphisms may have more accurate prediction of cancer prognosis compared with single polymorphism because of the modest …
AM Horgan, B Yang, AK Azad, E Amir, T John… - Journal of Thoracic …, 2011 - Elsevier
Introduction: Lung cancer is the leading global cause of cancer-related mortality. Interindividual variability in treatment response and cancer outcomes has focused attention …
A Coelho, A Nogueira, S Soares, J Assis… - Oncology …, 2018 - spandidos-publications.com
Identification of mechanisms that influence the therapeutic response and survival in patients with cancer is important. It is known that the genetic variability of the host, including …
Methods: The p53 codon 72 polymorphism was determined in tumour biopsies (n= 107) and matched blood samples (n= 19) in cervical cancer patients using polymerase chain reaction …
Abstract p 53 helps in maintaining genomic stability by undergoing cellular arrest, DNA repair or cellular apoptosis during DNA damage. So, as to find the association of p 53 Arg 72 …
L Boldrini, S Gisfredi, S Ursino, M Lucchi… - Cancer …, 2008 - Taylor & Francis
A total of 42 polymorphisms have been identified in the TP53 gene. The polymorphic site of p53 at codon 72 in exon 4 and p53PIN3, a 16 bp insertion/duplication in intron 3, are the …
WP Chien, RH Wong, TC Wu, YW Cheng… - Annals of surgical …, 2009 - Springer
Background Accumulated evidence suggests that p53 function altered by its gene mutation or genetic polymorphism contributes to tumor malignancy. Association of p53 mutation and …