The normal functioning of p53 is a potent barrier to cancer. Tumour-associated mutations in
TP53, typically single nucleotide substitutions in the coding sequence, are a hallmark of …

The p53 pathway has been extensively studied for its role in carcinogenesis. Disruption of
the pathway occurs in more than half of all cancers, often leading to a worse prognosis for …

Highly sensitive protein detection method based on nanoparticles and enzyme-linked
immunosorbent assays (ELISAs), named Nano-ELISA, was introduced. In this method, the …

Introduction Multiple biologically relevant polymorphisms may have more accurate
prediction of cancer prognosis compared with single polymorphism because of the modest …

Introduction: Lung cancer is the leading global cause of cancer-related mortality.
Interindividual variability in treatment response and cancer outcomes has focused attention …

Identification of mechanisms that influence the therapeutic response and survival in patients
with cancer is important. It is known that the genetic variability of the host, including …

Methods: The p53 codon 72 polymorphism was determined in tumour biopsies (n= 107) and
matched blood samples (n= 19) in cervical cancer patients using polymerase chain reaction …

Abstract p 53 helps in maintaining genomic stability by undergoing cellular arrest, DNA
repair or cellular apoptosis during DNA damage. So, as to find the association of p 53 Arg 72 …

A total of 42 polymorphisms have been identified in the TP53 gene. The polymorphic site of
p53 at codon 72 in exon 4 and p53PIN3, a 16 bp insertion/duplication in intron 3, are the …

Background Accumulated evidence suggests that p53 function altered by its gene mutation
or genetic polymorphism contributes to tumor malignancy. Association of p53 mutation and …