The re-emergence of natural products for drug discovery in the genomics era

AL Harvey, RA Edrada-Ebel, RJ Quinn - Nature reviews drug discovery, 2015 - nature.com
Natural products have been a rich source of compounds for drug discovery. However, their
use has diminished in the past two decades, in part because of technical barriers to …

Secondary metabolites from entomopathogenic Hypocrealean fungi

I Molnár, DM Gibson, SB Krasnoff - Natural product reports, 2010 - pubs.rsc.org
Covering: up to the end of February 2010 This review surveys the natural products
described from entomopathogenic Hypocrealean fungi, including their structures, biological …

Triggering cryptic natural product biosynthesis in microorganisms

K Scherlach, C Hertweck - Organic & biomolecular chemistry, 2009 - pubs.rsc.org
Natural products from microorganisms are a crucial source for novel therapeutics. Even so, it
seems that many valuable compounds are overlooked when culturing microbes under …

Development of novel drugs from marine surface associated microorganisms

A Penesyan, S Kjelleberg, S Egan - Marine drugs, 2010 - mdpi.com
While the oceans cover more than 70% of the Earth's surface, marine derived microbial
natural products have been largely unexplored. The marine environment is a habitat for …

Current approaches to exploit actinomycetes as a source of novel natural products

O Genilloud, I González, O Salazar… - Journal of Industrial …, 2011 - academic.oup.com
For decades, microbial natural products have been one of the major sources of novel drugs
for pharmaceutical companies, and today all evidence suggests that novel molecules with …

[HTML][HTML] Aspergillus section Nidulantes (formerly Emericella): Polyphasic taxonomy, chemistry and biology

AJ Chen, JC Frisvad, BD Sun, J Varga, S Kocsubé… - Studies in Mycology, 2016 - Elsevier
Aspergillus section Nidulantes includes species with striking morphological characters, such
as biseriate conidiophores with brown-pigmented stipes, and if present, the production of …

Evaluation of culture media for the production of secondary metabolites in a natural products screening program

KM VanderMolen, HA Raja, T El-Elimat, NH Oberlies - Amb Express, 2013 - Springer
Variation in the growing environment can have significant impacts on the quantity and
diversity of fungal secondary metabolites. In the industrial setting, optimization of growing …

Discovery of kibdelomycin, a potent new class of bacterial type II topoisomerase inhibitor by chemical-genetic profiling in Staphylococcus aureus

JW Phillips, MA Goetz, SK Smith, DL Zink… - Chemistry & biology, 2011 - cell.com
Bacterial resistance to known therapeutics has led to an urgent need for new chemical
classes of antibacterial agents. To address this we have applied a Staphylococcus aureus …

The re-emerging role of microbial natural products in antibiotic discovery

O Genilloud - Antonie Van Leeuwenhoek, 2014 - Springer
New classes of antibacterial compounds are urgently needed to respond to the high
frequency of occurrence of resistances to all major classes of known antibiotics. Microbial …

Enhancing the discovery of bioactive secondary metabolites from fungal endophytes using chemical elicitation and variation of fermentation media

MM Gakuubi, KC Ching, M Munusamy… - Frontiers in …, 2022 - frontiersin.org
Endophytic microorganisms are an important source of bioactive secondary metabolites. In
this study, fungal endophytes obtained from A* STAR's Natural Product Library (NPL) and …