That certain cell types in the central nervous system are more likely to undergo
neurodegeneration in Parkinson's disease is a widely appreciated but poorly understood …

Abstract Purpose of Review Parkinson's disease (PD) is a complex neurodegenerative
disorder, the aetiology of which is still largely unknown. Overwhelming evidence indicates …

Mitochondrial dysfunction represents a well-established player in the pathogenesis of both
monogenic and idiopathic Parkinson's disease (PD). Initially originating from the observation …

Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic
Parkinson's disease (PD). However, strategies aimed at ameliorating mitochondrial …

Parkinson's disease (PD) is the second most common neurodegenerative disease. About
2% of the population above the age of 60 is affected by the disease. The pathological …

Antigen presentation is essential for establishing immune tolerance and for immune
responses against infectious disease and cancer. Although antigen presentation can be …

James Parkinson first described the motor symptoms of the disease that took his name over
200 years ago. While our knowledge of many of the changes that occur in this condition has …

The early endosome (EE), also known as the sorting endosome (SE) is a crucial station for
the sorting of cargoes, such as receptors and lipids, through the endocytic pathways. The …

The dynamic processes of mitochondrial fission and fusion are tightly regulated, determine
mitochondrial shape, and influence mitochondrial functions. For example, fission and fusion …

Parkinson's disease (PD) is the second most common neurodegenerative disease. The
pathogenesis of PD is complicated and remains obscure, but growing evidence suggests …