Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

An essential step in renal function entails the formation of an ultrafiltrate that is delivered to
the renal tubules for subsequent processing. This process, known as glomerular filtration, is …

Alzheimer's disease (AD) is a progressive brain disorder associated with slow loss of brain
functions leading to memory failure and modest changes in behavior. The multifactorial …

Epilepsy is one of the most common neurological disorders characterized by recurrent
seizures. The mechanism of epilepsy remains unclear and previous studies suggest that N …

Recent studies have revealed the connection between amino acid chirality and diseases.
We have previously reported that the gut microbiota produces various d-amino acids in a …

Kidney diseases have become one of the most common health care problems. Due to a
growing number of advanced aged patients with concomitant disorders the prevalence of …

N-Methyl-D-aspartate glutamate receptors (NMDARs) are involved in multiple
physiopathological processes, including synaptic plasticity, neuronal network activities …

In neuroscience research, chiral metabolomics is an emerging field, in which D-amino acids
play an important role as potential biomarkers for neurological diseases. The targeted chiral …

REL-1017 (esmethadone) is a novel N-methyl-D-aspartate receptor (NMDAR) antagonist
and promising rapid antidepressant candidate. Using fluorometric imaging plate reader …

Obesity is one of the main causes of chronic kidney disease; however, the precise molecular
mechanisms leading to the onset of kidney injury and dysfunction in obesity-associated …