Articular cartilage is a load‐bearing tissue playing a crucial mechanical role in diarthrodial
joints, facilitating joint articulation, and minimizing wear. The significance of biomechanical …

Hyaline cartilage serves as a low-friction and wear-resistant articulating surface in load-
bearing, diarthrodial joints. Unfortunately, as the avascular, alymphatic nature of cartilage …

Biophysical cues play a key role in directing the lineage commitment of mesenchymal stem
cells or multipotent stromal cells (MSC s), but the mechanotransductive mechanisms at play …

Osteoarthritis is a degenerative joint disease characterized by pain and disability. It involves
all ages and 70% of people aged> 65 have some degree of osteoarthritis. Natural cartilage …

Loading is important to maintain the balance of matrix turnover in the intervertebral disc
(IVD). Daily cyclic diurnal assists in the transport of large soluble factors across the IVD and …

EXECUTIVE SUMMARY The University of Vermont College of Medicine and the Vermont
Lung Center, with support of the National Heart, Lung, and Blood Institute (NHLBI), the …

It is becoming increasingly clear that mesenchymal stem cell (MSC) differentiation is
regulated by mechanical signals. Mechanical forces generated intrinsically within the cell in …

Engineering the meniscus is challenging due to its bizonal structure; the tissue is
cartilaginous at the inner portion and fibrous at the outer portion. Here, we constructed an …

Mesenchymal stem cells (MSCs) are an attractive cell source for cartilage tissue engineering
given their ability to undergo chondrogenesis in 3D culture systems. Mechanical forces play …

Mechanical factors play a crucial role in the development of articular cartilage in vivo. In this
regard, tissue engineers have sought to leverage native mechanotransduction pathways to …