Chronic graft-versus-host disease (GVHD) is the leading cause of late, nonrelapse mortality
and disability in allogeneic hematopoietic cell transplantation recipients and a major …

Salivary glands produce and secrete saliva, which is essential for maintaining oral health
and overall health. Understanding both the unique structure and physiological function of …

Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is considered to be the
strongest curative immunotherapy for various malignancies (primarily, but not limited to …

Mesenchymal stromal cells (MSCs) are the subject of numerous clinical trials, largely due to
their immunomodulatory and tissue regenerative properties. Toll-like receptors (TLRs) …

The molecular pathways that regulate the tissue repair function of type I interferon (IFN-I)
during acute tissue damage are poorly understood. We describe a protective role for IFN-I …

Graft-versus-host disease (GvHD) is a common complication of hematopoietic cell
transplantation that negatively impacts quality of life in recipients and can be fatal. Animal …

The primacy of the gastrointestinal (GI) tract in dictating the outcome of graft-versus-host
disease (GVHD) is broadly accepted; however, the mechanisms controlling this effect are …

Compromised intestinal barrier function is a prominent feature of inflammatory bowel
disease (IBD). However, links between intestinal barrier loss and disease extend much …

Myeloid-derived suppressor cells (MDSCs) can subdue inflammation. In mice with acute
graft-versus-host disease (GVHD), donor MDSC infusion enhances survival that is only …

Gut microbiota has gained increasing interest in the pathogenesis of immune-related
diseases. In this context, graft-versus-host disease is a condition characterized by an …