Hypoxia-inducible factor as a bridge between healthy barrier function, wound healing, and fibrosis

CA Steiner, IM Cartwright, CT Taylor… - American Journal of …, 2022 - journals.physiology.org
The healthy mammalian intestine is lined by a single layer of epithelial cells. These cells
provide a selectively permeable barrier to luminal contents and normally do so in an efficient …

Modulation of Protein Disulfide Isomerase Functions by Localization: The Example of the Anterior Gradient Family

AS Pierre, N Gavriel, M Guilbard… - Antioxidants & Redox …, 2024 - liebertpub.com
Significance: Oxidative folding within the endoplasmic reticulum (ER) introduces disulfide
bonds into nascent polypeptides, ensuring proteins' stability and proper functioning …

Comprehensive analysis of endoplasmic reticulum stress-associated genes signature of ulcerative colitis

B Deng, F Liao, Y Liu, P He, S Wei, C Liu… - Frontiers in …, 2023 - frontiersin.org
Background Endoplasmic reticulum stress (ERS) is a critical factor in the development of
ulcerative colitis (UC); however, the underlying molecular mechanisms remain unclear. This …

Endoplasmic reticulum stress related genome-wide Mendelian randomization identifies therapeutic genes for ulcerative colitis and Crohn's disease

M Zou, Q Liang, W Zhang, Y Zhu, Y Xu - Frontiers in Genetics, 2023 - frontiersin.org
Background: Endoplasmic reticulum stress (ERS) is an important pathophysiological
mechanism in ulcerative colitis (UC) and Crohn's disease (CD). ERS-related genes may be …

[HTML][HTML] Multi-omics in Crohn's disease: New insights from inside

C Mu, Q Zhao, Q Zhao, L Yang, X Pang, T Liu… - Computational and …, 2023 - Elsevier
Crohn's disease (CD) is an inflammatory bowel disease (IBD) with complex clinical
manifestations such as chronic diarrhea, weight loss and hematochezia. Despite the …

Laser capture microdissection for biomedical research: Towards high-throughput, multi-omics, and single-cell resolution

W Guo, Y Hu, J Qian, L Zhu, J Cheng, J Liao… - Journal of Genetics and …, 2023 - Elsevier
Spatial omics technologies have become powerful methods to provide valuable insights into
cells and tissues within a complex context, significantly enhancing our understanding of the …

Natural compound fraxinellone ameliorates intestinal fibrosis in mice via direct intervention of HSP47-collagen interaction in the epithelium

J Wang, M Bai, C Zhang, N An, L Wan… - Acta Pharmacologica …, 2023 - nature.com
Intestinal fibrosis is a common complication of inflammatory bowel disease. There is still a
lack of effective drugs for the prevention or treatment of intestinal fibrosis. Heat shock protein …

Intestinal strictures in Crohn's disease: a 2021 update

X Lin, Y Wang, Z Liu, S Lin, J Tan, J He… - Therapeutic …, 2022 - journals.sagepub.com
Intestinal strictures remain one of the most intractable and common complications of Crohn's
disease (CD). Approximately 70% of CD patients will develop fibrotic strictures after 10 years …

PEPerMINT: peptide abundance imputation in mass spectrometry-based proteomics using graph neural networks

T Pietz, S Gupta, CN Schlaffner, S Ahmed… - …, 2024 - academic.oup.com
Motivation Accurate quantitative information about protein abundance is crucial for
understanding a biological system and its dynamics. Protein abundance is commonly …

Potential role of AGR2 for mammalian skin wound healing

AV Kosykh, MB Tereshina, NG Gurskaya - International Journal of …, 2023 - mdpi.com
The limited ability of mammals to regenerate has garnered significant attention, particularly
in regard to skin wound healing (WH), which is a critical step for regeneration. In human …