The primary β-globin gene mutation that causes sickle cell disease (SCD) has significant
pathophysiological consequences that result in hemolytic events and the induction of the …

Objective To evaluate socio‐economic and demographic determinants of anemia among
Indian children aged 6 to 59 months. Methods Statistical analysis was performed on the …

Sickle cell disease is a class of hemoglobinopathy in humans, which is the most common
inherited disease in the world. Although complications of sickle cell disease start from …

Sickle cell disease (SCD) is the first molecular disease in the literature. Although the
structural alteration and dysfunction of the sickle hemoglobin (HbS) are well understood, the …

Background Hematological changes can drive damage of endothelial cells, which
potentially lead to an early endothelial dysfunction in patients with sickle cell anemia (SCA) …

Objectives To investigate the associations between several sickle cell disease genetic
modifiers (beta-globin haplotypes, alpha-thalassemia, and glucose-6-phosphate …

Sickle cell disease (SCD) patients often exhibit a dyslipidemic sub-phenotype. Paraoxonase
1 (PON 1) is a serum glycoprotein associated with the high-density lipoproteins cholesterol …

Background Lipid peroxidation plays a very important role in sickle cell pathophysiology.
The formation of malondialdehyde (MDA) in patients with sickle cell disease (SCD) may lead …

Oxidative stress and haemolysis‐associated nitric oxide (NO) depletion plays a crucial role
in the development of vasculopathy in sickle cell anaemia (SS). However it remains …

Accelerated oxidative damage is one of the hallmarks in both sickle cell disease (SCD) and
thalassemia major (TM). A decreased antioxidant level is found in both diseases. Our study …